Aynu ka hadalno hydroxypropyl methyl cellulose HPMC iyo sida loo cabbiro viscositykeeda.Viscosity-ka halkan waxaa loola jeedaa viscosity muuqda, kaas oo tixraac muhiim ah u ah hydroxypropyl methyl cellulose.
Heerka.Hababka cabbiraadda caadiga ah waa cabbiraadda viscosity-ka wareeg, cabbirka viscosity capillary iyo cabbirka viscosity cabbirka.Habka lagu go'aamiyay hydroxypropyl methyl cellulose wuxuu ahaa adhesion capillary.
Habka go'aaminta shahaadada, iyadoo la adeegsanayo fiisada Uchs.Caadiyan go'aaminta xalku waa 2% xal aqueous ah, qaacidadu waa: V=Kdt.V waa viscosity ee mpa.s iyo K waa viscometer joogto ah.
D waa cufnaanta heerkulka joogtada ah T waa wakhtiga kor ilaa hoos ilaa viscometer-ka ilbiriqsiyo gudahood.Habkan hawlgalka ah ayaa aad u dhib badan, haddii ay jirto arrin aan la milmi karin.
Erayada way fududahay in khaladaad la keeno, way adagtahay in la aqoonsado tayada hydroxypropyl methyl cellulose.Hadda waxaa caadi ahaan loo isticmaalaa in lagu cabbiro viscosity ee viscometer-ka wareegga, isticmaalka guud ee Shiinaha.
Qaabka NDJ-1 viscometer waa η=KA.η waa viscosity, sidoo kale gudaha mpa.s, K waa iskudarka viscometerka, αna waa akhrinta tilmaame viskometer.
Hydroxypropyl methyl cellulose 2% habka tijaabada viscosity:
1, habkani wuxuu ku habboon yahay go'aaminta viscosity firfircoon ee dareeraha aan Newtonian ahayn (xalka polymer, ganaax, dareeraha dareeraha emulsion ama xal surfactant, iwm.).
2. Qalab iyo qalab
2.1 Viscometer Rotary (NdJ-1 iyo NDJ-4 waxaa looga baahan yahay Pharmacopoeia Shiinaha)
2.2 Qubeyska heerkulka joogtada ah ee heerkulka joogtada ah saxnaanta heerkulka joogtada ah 0.10C
2.3 Heerkulka heerkulku waa 0.20C, kaas oo mar mar la xaqiijiyo.
2.4 Viscometers mitirka inta jeer ee la isticmaalayo cabbirada xasilinta soo noqnoqda (sida NDJ-1 iyo NDJ-4) waa in la xafidaa.Saxnimada 1%.A
8. Og muunada si sax ah ayaa loo miisaamay waxaana lagu riday digsi dheer oo 400ml ah oo qalalan.Ku dar qiyaastii 100ml oo ah 80-90 digrii biyo kulul oo walaaq 10min si aad u kala soocdo
Si siman u kala firdhi, walaaq oo ku dar biyo qabow 400mL guud ahaan.Dhanka kale, si joogto ah u walaaq ilaa 30min si aad u sameyso 2% (W/W), qaboojiyaha ku rid qaboojiyaha barafku si uu u qaboojiyo ilaa uu ka sameeyo baraf dhuuban oo korka ah.
Soo saar oo ku rid haanta heerkulka joogtada ah si aad heerkulka dhexe ugu ilaaliso 20 ℃ 0.1 ℃.
3.1 Rakibaadda iyo hawlgalka qalabka waa in lagu fuliyaa si waafaqsan tilmaamaha hawlgalka ee qalabka, iyo rotor iyo rotor ku haboon waa in la doortaa iyadoo la raacayo kala duwanaansho viscosity ee alaabta la tijaabiyey iyo bixinta farmasopoeia ee hoos qoraalka qoraalka ah. alaabta
Xawaaraha wareega
3.2 Isku hagaaji heerkulka biyaha ee joogtada ah iyadoo loo eegayo go'aaminta shay kasta oo daroogo ah.
3.3 Badeecada tijaabada waxaa lagu riday weelka lagu qeexay aaladda, xagasha leexinta (a) waxaa lagu cabiray si waafaqsan sharciga kadib 30 daqiiqo oo heerkul joogto ah.Demi mootada oo dib u bilow si aad u go'aamiso mar kale
Farqiga u dhexeeya qiimaha celceliska waa inuusan dhaafin 3%, haddii kale cabbir saddexaad waa in la sameeyaa.
3.4 Xisaabi celceliska qiimaha labada imtixaan sida waafaqsan qaacidada si aad u hesho viscosity fir fircoon ee alaabta la tijaabiyay.
4. Qor oo xisaabi
4.1 Diiwaangeli nooca viscometerka wareega, lambarka rotor-ka iyo xawaaraha la isticmaalay, viscometer joogto ah (K 'qiimaha), heerkulka la qiyaasay, iyo cabbir kasta.Qiimaha.
Qaaciddada xisaabinta ee 4.2
Viscosity Dynamic (MPa”s)=Ka halka K uu yahay muuqalaha joogtada ah ee lagu cabbiro dareeraha caadiga ah ee viscosity-ga la yaqaan iyo A waa xagasha leexinta
Waqtiga boostada: Meey-18-2022