Diyaarinta iyo astaamaha ee hydroxypropyl methylrcellesulose

Hydroxypropyl methylrcellulose(HPMC) waa shey polymer dabiici ah oo leh ilo badan oo ilo badan, oo la cusbooneysiin karo, iyo salaan wanaagsan oo biyo ah iyo astaamaha sameynta filimka. Waa shey ceyriin ah oo ku habboon diyaarinta filimada baakadaha biyaha-ku-milma.

Filimka baakadaha biyaha-ku-milicsan waa nooc cusub oo shey cagaaran oo cagaaran, kaas oo helay feejignaan ballaaran oo ka dhacay Yurub iyo Mareykanka iyo waddamada kale. Kaliya ma aha badbaado oo ku habboon in la isticmaalo, laakiin sidoo kale xalliya dhibaatada qashin-qubka. Waqtigan xaadirka ah, filimada biyaha-milmi-biyaha ayaa inta badan isticmaala walxaha ku saleysan batroolka sida aalkolada polyvinyl iyo polyetylnene ovide sida alaabada ceyriinka ah. Batroolka waa ilo aan cusboonaysiin karin, iyo isticmaal ballaaran ayaa sababi doona yaraanta kheyraadka. Waxa kale oo jira filim-biyo-ku-milicsiga iyadoo la adeegsanayo walxaha dabiiciga ah sida istaarijka dabiiciga ah sida istaarijka iyo borotiinka sida qalabka ceyriinka ah, laakiin filimadan biyaha lagu milagowdo ayaa leh guryo farsamo oo liita. Waraaqdan, nooc cusub oo ka mid ah filim ka buuqa biyaha biyaha lagu buufiyo ayaa loo diyaariyey xalka ka saarida habka filimka sameynta iyadoo la adeegsanayo hydroxypropyl metylcelrelouse sida shey ceyriin ah. Saamaynta Foot-ka ee Foomka 'HPMC' ee Foot-Ploviline Flive-ka iyo Fooqiijinta Foot-Finile Awooda Turnile, Elonnation-ka nasashada, iftiinka nalka, xarkaha khafiifka ah iyo jilitaanka biyaha ee filimada xirmooyinka biyaha ee HPMC ayaa laga wada hadlay. Glycerol, Sorrotl iyo Glutaraldehyde ayaa loo adeegsaday in lagu sii wanaajiyo waxqabadka filimka ka buuqa biyaha ee HPMC. Ugu dambeyntiina, si loo ballaariyo arrinta xirmada baakadaha biyaha ee biyaha ee HPMC ee baakadaha cuntada, bamboo caleenta antioxidant (aob) ayaa loo isticmaalay in lagu hagaajiyo astaamaha anti -xidat ee filimka ka buuqa biyaha ee HPMC. Natiijooyinka ugu waaweyn waa sida soo socota:

(1) Iyada oo kororka feejignaanta HPMC, xoogga khasabka ah iyo ciriiriga fasaxa filimka HPMC ayaa kordhay, halka khafiifka uu ka gudbo khafiifka. Marka feejignaanta HPMC ay tahay 5% iyo heerkulka qaab-dhismeedka filimka waa 50 ° C, oo ah astaamaha dhameystiran ee filimka HPMC ayaa ka fiican. Waqtigaan, xoogga khafiifka ah waa qiyaastii 116mpa, wareegga nasashada waa qiyaastii 31%, transming transming-ka waa 90%, iyo waqtiga biyuhu waa 55min.

(2) Calaamadka caatada ah ee Glycerol iyo Sortol waxay wanaajiyeen astaamaha farsamada ee filimada HPMC, oo si weyn u kordhay dalaggooda fasaxa. Markii ay nuxurka Glycel-ka uu u dhexeeyo 0.05% iyo 0.25%, saameynta ayaa ah waxa ugu fiican, iyo wareegga nasashada filimka baakadaha biyaha ee HPMC ay gaarayaan 50%; Marka nuxurka sirtlol waa 0.15%, qulqulka nasashada oo kordhaya 45% ama wax ka badan. Ka dib markii filimka 'HPMC' ee ay ka beddeleen filimka 'HPMC' oo lagu beddelay glycerol iyo sortol, xoogga khasabka ah iyo guryaha indhahacaddu ay yaraadeen, laakiin dhimistu muhiim ma ahayn.

(3) Spectroscopy-ka (Ftiir) filimka 'glutaraldehyde-cropling' oo ka buufiyey 'glutladehydyde' oo ay muujisay in glutaraldehyde ay ku xiran tahay filimka, yareynta xariga-xariga biyaha ee xirmada baakadaha biyaha ee HPMC. Marka lagu daro Glutaraldehyde wuxuu ahaa 0.25%, guryaha farsamada, iyo astaamaha indhaha ee filimaanta ayaa si fiican u gaadhay. Markii lagu daro Glutaraldehyde wuxuu ahaa 0.44%, waqtiga biyuhu ku sii jeedo 135 daqiiqo.

(4) Ku darista xaddi ku habboon ee AOB ee Xalka Sawirka 'HPMC' ee 'HIPMC' ee xalka filimka '' '' '' '' '' '' '' '' 'ay horumarin karaan guryaha ka hortagga anti -xident ee filimka. Marka 0.03% lagu daray filimka 'aOb / HPMC' wuxuu lahaa heer jajaban oo qiyaastii 89% ah xag-jirnimada bilaashka ah, taas oo ka sarreysay tii filimka HPMC ah oo aan la helin si moobo la'aan ah.

Erayada Muhiimka ah: filim baakadaha biyaha-ku-milma; hydroxypropyl methylcelrelose; balaastiyad; wakiilka isku xirka iskuxirka; antioxidant.

Jadwalka waxyaabaha ku jira

Soo Koobid ..................................................... ............................................... ......................

Shaqada ......................................................

Tusmada waxyaabaha ku jira ................................................ ............................................. ...............................

CUTUBKA Hordhac ............................................ ............................................................... ..1

1.1.1ware-filim '..........................................................................................

1.1.1.1APOLYVINYL Aalkolada (PVA) filim biyo-milicsan ......................................................................

1.1.2polyetynene oxide (peo) filim biyo-milicsan ....................................................................

1.1.

1.1.4 filimaan-ku-saleysan biyo-ku-saleysan ....................................................................

1.2 hydroxypropyl methylcelrellase ..............................................................................

1.2.1 Qaab dhismeedka hydroxypropyl methylcelrellase ............................................................................

1.2.2 Xoolaha biyaha ee biyaha ee hydroxypropylyl methylcelrellase ...................................................................... 4.

1.2.3 Guryaha Filimka ee Samaynta Hydroxypropylkylkellellase ............................................. .4 .4 .4

1.3 Wax ka badalida balaastikada ee hydroxypropyl playlcelrellose filim ....................................... ..4

1.4 Wax ka badalista isku xirka isku xirka ee Hydroxypropyl Mykelcellesulose filim ......................................... .5

1.5 Guryaha antioxidat ee guryaha hydroxypropyl pluylcelrelose filim ............................................ 5

1.6 Soo-jeedinta mawduuca .................................................................. ............................................... ..7

1.7 Daraasad Daraasad ............................................................................................................... ...7

Cutubka 2 Diyaarinta iyo Guryaha ee Hydroxypropyl Mykyl Methyl Melule oo ka buuqa 'plululle' oo biyo-kululayaal ah ...........................................................................................................

2.1 Hordhac .................................................... 8

2.2 Qeybta Tijaabada .................................................................... ..................................................... ..8

2.2.1 Qalabka tijaabada ah iyo aaladaha ............................................................ ......... ..8

2.2.2 Diyaarinta Sampment ......................................................................... ..9

2.2.3 Cilmibaadda iyo imtixaanka Waxqabadka .............................

2.2.4 Ka shaqeynta xog-haynta ................................................ .............................................................................. 10

2.3 Natiijooyinka iyo wadahadalka .................................................................................

2.3.1 Saamaynta filim-filim-ka-dhigista Filimka xalka filimka khafiifka ah ee HPMC ................................................................................ 10

2.3.2 Saamaynta Heerkulka Samaynta Filimka ee Filimada Khafiifka ah ee HPMC ................................................................................................. ..13 ..13

2.4 Soo Koobid Cutubka cutubka ......................................................................................... .. 16

Cutubka 3 Saameynta

3.1 Hordhac ..................................................................................... .. 17

3.2 Qeybta Tijaabada .................................................................................

3.2.1 Qalabka tijaabada ah iyo aaladaha ..................................................................

3.2.2 Diyaarinta Sampment ................................................................

3.2.3 Cilmibaadda iyo imtixaanka Waxqabadka ................................................................... ..18

3.2.4 Xogdashadda xogta .................................................................................... ......................................... ..19

3.3 Natiijooyinka iyo wadahadalka .........................................................................

3.3.1 Saamaynta Glycel iyo Sortol on offrum offrum offrum of Filimyada khafiifka ah ee HPMC ................................................................... .1

3.3.2 Saamaynta Glycerol iyo Sortol on qaababka XRD ee filimada khafiifka ah ee HPMC ..................................................................................... ...20

3.3.3 Effects of glycerol and sorbitol on the mechanical properties of HPMC thin films……………………………………………………………………………………………………………………………………….21

3.3.4 saamaynta Glycerol iyo Sortol on Guryaha indhaha ee filimada HPMC ............................................................................................................

3.3.5 Saamaynta Glycerol iyo Sortol on Naafadda Biyaha ee Filimada HPMC .......... 23

3.4 Cutubka cutubka ............................................................................................... ..24

Cutubka 4aad Saamaynta wakiilada isku-dhafka ah ee ku saabsan filimyada baakadaha biyaha ee HPMC-ka-eega ee HPMC .............................................................................................

4.1 Hordhac ........................................................................................ 25

4.2 Qeybta Tijaabada ......................................................................................

4.2.1 Qalabka tijaabada ah iyo aaladaha .....................................................................]

4.2.2 Sampmen Diyaarinta ....................................................................................... ..26

4.2.3 Cilmibaadda iyo imtixaanka Waxqabadka ........................................... .. ............ .26

4.2.4 Xog-hawleed .......................................................................... ......................................... ..26

4.3 Natiijooyinka iyo wadahadalka ...............................................................................

4.3.1 Caqliga soo nuugista oo ka soo baxa ee xijaabka Glutaraladdehyde-FlivC MPMC Flives HPMC ........................................................................................................................................................... ..27

4.3.2 XRD Qaababka XRD ee Glutaraladdehyde Cross-LpMC Flivs Flivs oo Khafiif ah ..................................27

4.3.3 Saamaynta Glutaraldehyde ee salluumaynta biyaha ee filimada HPMC ................... ..28

4.3.4 Saamaynta Glutarardehyde ee ku saabsan guryaha farsamada ee filimada khafiifka ah ee HPMC ... 29

4.3.5 Saamaynta Glutarardehyde ee Glotaladehy ee Guryaha indhaha ee filimada HPMC .........................

4.4 cutubka Soo Koobid ................................................................................. ..

Cutubka 5aad ee dabiiciga ah ee dabiiciga ah ee 'antioxidander'

5.1 Hordhac ...............................................................................................

5.2 Qaybta Tijaabada ...................................................................................

5.2.1 Qalabka tijaabada ah iyo aaladaha tijaabada ah .......................................................... 31.

5.2.2 Diyaarinta Sampment ..................................................................................................... .32 .32

5.2.3 Cilmibaadda iyo imtixaanka Waxqabadka ..........................................................

5.2.4 Ka shaqeynta xogta .................................................................................... ................................................................ 33

5.3 Natiijooyinka iyo Falanqaynta ...........................................................................

5.3.1 falanqaynta FT-IR .............................................................................................. 33.

5.3.2 Falanqaynta XRD ................................................................................................. ..34

5.3.3 Guryaha antioxidant ............................................................................................

5.3.4 Xoolasho biyo ah .....................................................................

5.3.5 Guryaha farsamada ................................................................................................. ..36

5.3.6 Waxqabadka indhaha ........................................................................................

5.4 Dhan cutubka .....................................................

Cutubka 6aad gabagabada ............................................................ ..................................................39

Tixraacyo ......................................................

Soosaarista cilmi baarista inta lagu gudajiro daraasadaha shahaadada .................................................................................44 ..44

Mahadnaq ..........................................................

CUTUBKA Hordhac

Sida kahadalka cagaaran oo cagaaran oo cusub, filim baakadaha biyaha-ku-milmi ah ayaa si weyn loogu adeegsaday baakada alaabada kala duwan ee dalal shisheeye (sida Mareykanka, Japan, Faransiiska, iwm.) [1]. Filimka biyaha-milka, maadaama magacku muujinayo, waa filim caag ah oo lagu kala diri karo biyaha. Waxay ka samaysan tahay waxyaabo biyo-ku-sifeyl-biyo-ku-mil-ka ah oo ku dhex milmi kara biyaha oo waxaa diyaariyey geedi socod qaab dhismeedka gaarka ah leh. Sababo la xiriira guryaheeda gaarka ah, waxay aad ugu habboon tahay dadka inay xirxiraan. Sidaa darteed, cilmi baadhayaal aad u tiro badan ayaa bilaabay inay fiiro gaar ah u yeeshaan shuruudaha kahortagga deegaanka iyo ku habboonaanta [2].

1.1 filim-biyo-ku-milma

Waqtigan xaadirka ah, filimada biyaha-militariga ah ayaa inta badan ah filimyada biyaha-milmi-ku-milma iyadoo la adeegsanayo aalkolada ku saleysan ee polyvinyl iyo polyetyvylne oxide sida ashyaa'da ceyriinka ah, iyo filimada biyaha lagu milmi karo sida istaarijka iyo borotiinka aaladda ceyriinka ah.

1.1.1.1 polyvinyl aalkolada (PVA) filim biyo-ku-milma

Waqtigan xaadirka ah, filimada ugu badan ee biyaha lagu isticmaalo ee adduunka ayaa inta badan ah filimada PVA ee biyaha kululaya. PVA waa bakteeriyada vinyl polmy-ka oo loo isticmaali karo ilo kaarboonka iyo ilaha tamarta, waxaana lagu soo daadgureeyaa ficillada bakteeriyada iyo enzymes (3]] Filimka PVA wuxuu leeyahay guryo farsamo oo wanaagsan, laqabsasho adag iyo ilaalin deegaan wanaagsan. Waxaa si weyn loo isticmaalay oo wuxuu leeyahay heer sare oo ganacsi. Waa ilaa iyo inta ugu badan ee loo adeegsado iyo kuwa ugu weyn ee kahada-ka-eegida ee suuqa 'ee suuqa' 5]. PVA waxay leedahay sharafdarro wanaagsan waxaana loo dajin karaa sheyga si uu u dhaliyo CO2 iyo H2O carrada [6]. Inta badan cilmi baarista filimada biyaha-lagu milato ayaa hadda ah in wax laga beddelo loona dhexdiyo si ay u helaan filim biyo-ku-milicsan. Zhao Linlin, Xiong Hanguo [7] waxay bartay diyaarinta filim ka buuqa biyaha ee PVA-da, waxayna go'aamisay tirada ugu weyn ee PVAw, oo Gellycel 5%, sodium dodecyl sulfate (SDS) 4%. Ka dib qalajinta mikrowave ee filimka la helay, waqtiga biyaha-lagu milmay ee biyaha heerkulka qolka waa 101s.

Ka gargaaridda xaalada cilmi baarista ee hadda jirta, filimka PVA ayaa si ballaaran loo adeegsadaa, qiimo jaban, iyo mid aad u fiican guryaha kala duwan. Waa sheyga baakadaha biyaha ugu fiican ee biyaha ku habboon. Si kastaba ha noqotee, maaddaama shey ku saleysan batroolka, PVA waa ilo aan cusboonaysiin oo aan dib loo cusbooneysiin karin, oo geedi socodka wax soo saarka ee ceyriinka ah ayaa wasakheyn kara. In kasta oo Mareykanka, Japan iyo dalal kale ay ku taxeen inay yihiin walax aan sun ah, nabadgelyadeeda wali waxay u furan tahay su'aal. Labada neef-neefsashada iyo is-nuujinta labadaba waxay waxyeelo u leeyihiin jirka [8], oo laguma magacaabi karo kimistariga cagaaran oo dhammaystiran.

1.1.2 polyethynene ovide (peo) filim biyo-ku-milma

Polyetylene oxide, oo sidoo kale loo yaqaan polyetylene oxide, waa heerkul, polymer-biyo-ku-mil-ka ah oo lagu qasin karo biyo ah heerkulka qolka [9]. Qaacida qaab dhismeedka ee polyetylene-ka oxide waa h - (- och2ch2-) n-oh, iyo cufnaanta molikal ee qaraabada ah waxay saameyn ku yeelan doontaa qaab dhismeedkeeda. Marka miisaanka molikalalbalal uu ku jiro tirada 200 ~ 20000, waxaa lagu magacaabaa polyethylen glycol (peg), iyo culeyska molecular waxay u yeeri karaan polyetylnene oxide (10]. Peo waa budo jilicsan oo jilicsan oo jilicsan, kaas oo fududahay in la socodsiiyo oo loo qaabeeyo. Filimaanta POO ayaa sida caadiga ah lagu diyaariyaa iyadoo lagu daro qalabka caagga ah, xasilinta iyo waxyaabaha la buuxiyo ee loo yaqaan 'pemoplas' iyada oo loo marayo howl-wadeenno heerkul ah [11].

Filimka POE waa filim biyo-milix ah oo leh madax xanuun biyo ah, oo guryaha farsamada leh sidoo kale, laakiin xaalado xaalado adag, oo saameyn gaar ah ku yeelata jawiga, oo ay ku leeyihiin inta badan howlihii ugu waaweynaa waa la isticmaali karaa. PVA Filim Filimka (12]. Intaas waxaa sii dheer, POE sidoo kale wuxuu leeyahay sunta ah, sidaa darteed si dhif ah looma isticmaalo baakadaha wax soo saarka [13].

1.1.3 GUUD EE STARCH-SOLUPLE

Stralch waa polyper-ka molialalbalal ee dabiiciga ah, oo moleekulayaasheed waxay ka kooban yihiin kooxo badan oo hydroxyl, sidaa darteed istaarijka ayaa ku adag in la qaboojiyo, sidaa darteedna waa ay adag tahay in lala macaamilo pomoom kale. wada jir ah [14,15]. Xoolaha biyaha ee istaarijka ayaa liita, waxayna qaadataa waqti dheer in lagu dhex baxo biyaha qabow, oo ah istaarijka isbedelka, taasi waa, in inta badan loo isticmaalo diyaarinta filimada biyaha lagu milago. Guud ahaan, istaarijka waxaa lagu beddelaa qaabab ay ka mid yihiin sidii wax loo dhiso, xiliil, grafting, iyo isku xirnaanta isku-darka qaab dhismeedka istaariska, iyadoo lagu wanaajiyo biyaha-xabiilka-istared [7,16].

Ku soo bandhig bogaadin ethr ah oo iskutallaab ah oo loo yaqaan 'istaarijka isku-darka' 'Cilmi' Si kastaba ha noqotee, heerkulka hoose, filimka istaarijka ah wuxuu leeyahay dhismayaal farsamo oo liita iyo daahfurnaan liita, sidaa darteed xaaladaha badankood, waxay u baahan tahay in lagu dhowaado agabyada kale sida PVA, iyo qiimaha isticmaalka dhabta ah ma sareyso.

1.1.4 biyo-ku-saleysan-ku-saleysan-ku-saleysan

Borotiinku waa walax-bayoolous dabiici ah oo firfircoon oo ay ku jiraan xayawaannada iyo dhirta. Maaddaama inta badan walxaha borotiinka ah ay ku dhex jiraan biyaha heerkulka qolka, waxaa lagama maarmaan ah in la xalliyo xalinta xariga xariga borotiinnada biyaha ee heerkulka qolka si loogu diyaariyo filimada qolka oo ay ku jiraan borotiinno ah. Si loo hagaajiyo jilidda xaaska borotiinnada, waxay u baahan yihiin in wax laga beddelo. Hababka wax-ka-beddelka kiimikada ee caadiga ah waxaa ka mid ah hoos u dhac, phthalomindation, phosphoryration, iwm; Saamaynta wax ka badalida ayaa ah in la beddelo qaab dhismeedka unugyada borotiinka, taas oo kordhaysa xaruudda, gration-ka, waxqabadka, kuwa wax ka qabashada biyaha iyo xasilloonida ayaa buuxisa baahiyaha wax soo saarka iyo socodsiinta. Guulihii biyaha ku saleysan ee borotiinka-ku-saleysan waxaa lagu soo saari karaa iyada oo loo adeegsado qashinka abuurka iyo dhirta dhirta sida timo-hoosaadka xayawaanka, ama ku takhasusay soosaarka warshadaha ceyriinka ah, oo aan loo baahnayn in ay saameyn yar ku yeeshaan bayrta [19]. Si kastaba ha noqotee, filimada biyaha ee ay diyaariyeen isla borotiin isku mid ah matrix waxay leeyihiin astaamo farsamo oo liita iyo jilib biyo ah oo hooseeya heerkulka hooseeya ama heerkulka qolka, si baaxaddooda ah ay u cidhiidhi yihiin.

Isugeynta, waxay muhiimad weyn u leedahay in la sameeyo wax cusub oo cusboonaysiin ah, oo la cusbooneysiin karo, oo ah baakadaha filim-biyoodka biyaha leh oo leh wax qabad aad u wanaagsan oo lagu wanaajiyo cilladaha filimada biyaha ee hadda jira.

Hydroxypropyl bylulose (hydroxypropyl bylulose) waa sheybaar dabiici ah, laakiin sidoo kale aan ahayn mid aan sun lahayn, oo aan la tartamin dadka cuntada, iyo ilaha la cusboonaysiin karo ee badan ee dabiiciga ah [20]]. Waxay leedahay culeys biyo ah oo wanaagsan iyo astaamo sameynta filim, waxayna leedahay xaaladaha diyaarinta filimada baakadaha biyaha-ku-milma.

1.2 hydroxypropyl methylrcellulose

Hydroxypropyl bylule (hydroxypropyl bylule, HIPMC muddo gaaban), ayaa sidoo kale loo soo gaabiyey ceyriska dabiiciga ah, wax ka beddelidda sacab, wax ka badalida ethilisa, wax ka beddelka iyo haynta lagu maydho iyo habsashada iyo habsamidda dharka lagu dhaqo. Biyo-biyoodka biyaha-lagululeeyo [21]. Hydroxypropyl methylcelrellase waxay leedahay astaamaha soo socda:

(1) ilo badan oo la cusbooneysiin karo. Qaybta ceeriin ee hydroxypropylyl methylcelrelolose waa unugyada ugu badan ee dabiiciga ah ee ugu badan dhulka, oo ay iska leedahay ilaha dabiiciga ah ee dabiiciga ah.

(2) bey'adda bey'adda u fiican iyo noolaha la isticmaali karo. Hydroxypropylkyl methylcelrelose waa sun aan wax khatar ahayn oo aan waxyeello u lahayn jirka bini aadamka waxaana loo isticmaali karaa daawada iyo warshadaha cuntada.

(3) Isticmaalka ballaaran ee ballaaran. Iyada oo ah shey-biyo-dhiig-biyo-biyo-dhiig-biyo-dhiig ah methylcelrellose waxay leedahay culeys biyo ah, kala-duwan, qaro, oo si weyn loo isticmaali karo agabyada dhismaha, oo ah kiimikooyin, xargaha, iyo elektiroonigga iyo beeraha kale ee warshadaha ah [21].

1.2.1 Qaab dhismeedka hydroxypropyl methylrcellulose

HPMC waxaa laga soo qaatay cellole dabiici ah ka dib marka laga soo qaado alkalization, oo qayb ka mid ah polyhydroxypropyl ether ether iyo methyl waxaa lagu xusayaa prethylnenene iyo methyl chloride oxide iyo methyl chloride. Shahaadada guud ee ganacsiga ee HPMC methyl beddelaynta laga bilaabo 1.0 illaa 2.0, iyo heerka heerka kuleylka ee 'hydroxypropypyple' oo ka kooban 0.1 illaa 1.0. Qaaciddadeeda molikalaulal waxaa lagu muujiyey Jaantuska 1.1 [22]

Sababo la xiriira isku xirka Hydrogen ee xoogga leh ee udhaxeeya Macromoleeces-ka dabiiciga ah ee dabiiciga ah, way adagtahay in lagu baabi'iyo biyaha. Xoogga unugyada kabista ee loo yaqaan 'Etherlulose' ee biyaha la kariyey ayaa si weyn loo wanaajiyaa sababta oo ah Ether ayaa lagu soo rogay qolo kahortagga etherfan, kaas oo baabi'inaya xaraashka hydrogen-ka ee u dhexeeya moleekuleynta unugyada waxayna kordhisaa xabayadeeda biyaha [23]]. @Droxypropylylulolose (HPMC) waa mid caadi ah oo hydroxyalykyl alkyl '[21], @ -Cyrexyranose' 'glucopopyranose', @3-ka), oo aan la koobi karin oo ka kooban @et- (ch3), waxqabadka cellulose waa mid dhameystiran milicsiga isuduwidda iyo tabaruca koox kasta. - [OCH2CH (ch3)] n Oh the yoh youxyl End The Now Group-ka waa koox firfircoon, oo silsiladaha la jajaban yahay, oo ay saameyn ku yeelato saameyn ku-meel-gaar ah oo ku saabsan silsiladda macruufka ah; -Coch3 waa koox dhamaad ah, goobta falcelinta ayaa la fududeyn doonaa ka dib beddelka, oo ay iska leedahay koox-qaade-gaaban [21]. Kooxaha hydroxyl ee silsiladda laanta cusub ee lagu daray iyo kooxaha hydroxyl ee ka harsan haraaga gulukooska waxaa wax ka beddeli kara kooxaha kor ku xusan, taasoo dhalisay qaab dhismeedka aadka u adag iyo guryaha la isku hagaajinta ee ku jira tirada tamar ee qaarkood [24].

1.2.2 Xoolaha biyaha ee biyaha ee hydroxypropyl methylrcellulose

Hydroxypropylykyly methylcelrelose waxay leedahay guryo badan oo aad u fiican qaab dhismeedkeeda gaarka ah, waxa ugu caansan ee ay tahay salka ay ku noolaadaan. Waxay ku barartaa xalka fidsan ee biyaha qabow, xalkana wuxuu leeyahay waxqabad dusha sare ah, hufnaan sare iyo waxqabadka xasilloon [21]. Hydroxypropylylulose rugylcelrelose dhab ahaantii waa la soo saaray cherylcellolose, sidaa darteed waxay wali haysataa astaamaha isbarbardhiga biyaha-kulul iyo bulsheed biyo kulul oo la mid ah metylcellosuse [21], iyo cunidda biyaha ee biyaha la hagaajiyay. Uurka methyl wuxuu u baahan yahay in lagu meeleeyo 0 illaa 5 ° C 20 ilaa 40 daqiiqo si loo helo xalka wax soo saarka daahfurnaanta wanaagsan iyo Viscosity deggan [25]. Xalka ee HydroxypropylyLrelolose Shayga ayaa kaliya u baahan inuu noqdo 20-25 ° C si loo gaaro xasillooni wanaagsan iyo daahfurnaan wanaagsan [25]. Tusaale ahaan, jajaban hyroxypropyl methylcelrellose (Qaabka grasanular 0.2-0.5 mm) ayaa si fudud loogu kala diri karaa biyaha heerkulka qolka oo aan qaboojin 4% xalka aqueous ay gaareyso 2000 centipoise 20 ° C.

1.2.3 Guryaha-filimka-sameynta filimka ee hydroxypropyl methylrcellulose

Hydroxypropylyplrcellellose xalka ayaa leh guryo aad u wanaagsan oo qaab dhismeedka ah, kaas oo bixin kara shuruudo wanaagsan oo ku saabsan deyrka dawada diyaarinta. Filimka dahaarka ah ee uu sameeyay waa midab la'aan, ur, ur, adag oo hufan [21].

Yan Yanzhong [26] wuxuu adeegsaday tijaabo orthogonal ah si uu u baaro astaamaha qaab-dhismeedka filimka ee versisroxypropyl methylcellosuse. Baadhitaanka waxaa lagu fuliyay seddex heerar oo ay weheliso uruurin kala duwan iyo koollo kaladuwan sida arrimaha. Natiijooyinka ayaa muujinaya in ku daraya 10% hydroxypropyl methylulolose ee mashiinka 50% ethanol ay yeelato astaamaha filimka ugu fiican, waxaana loo isticmaali karaa astaan ​​qaab-dhismeedka filimada daroogada ee sii socota.

1.1 Wax ka badalida balaastikada ee hydroxypropyl methylcellosuse filimka

Iyada oo ah ilo cusboonaysiin dabiici ah, filimka lagu diyaariyey cellulose maaddaama shey ceyriin ah uu leeyahay xasillooni wanaagsan iyo wax-u-habeyn, oo waa mid noole ah ka dib markii la tuuro, taas oo aan dhib lahayn deegaanka. Si kastaba ha noqotee, filimada unugyada unugyada ee aan la cayimin ayaa leh adkeyn liidata, iyo cellulose waxay noqon kartaa mid la istcimaalo oo wax laga badali karo.

[27] Waxaa loo adeegsaday Triethyl Citrat iyo acetyl tertrabutyl citrate si loo miiqdo oo wax ka beddelo saxarada unugyada unugyada unugyada. Natiijooyinka ayaa muujinaya in go'doominta nasashada ee filimka unugyada unugyada unugyada ah ee loo yaqaan 'choretate'

Luubuii et al [28] uu bartay saameynta ay ku waxyeeloobaan glycerol, aashito aashito iyo gulukoos ku yaal astaamaha farsamada ee metructose. Natiijooyinka ayaa muujinaya in heerka dalaga ee xuubka methyl-ka methy-ka uu ahaa markii ay ka kooban tahay in glycel ay ahayd 1.5%, iyo saamiga dalaga ee ku-darka 'metrulles melucose' oo ka kooban gulukoos iyo steratic aciddu waxay ahayd 0.5%.

Glycerol waa midab aan midab lahayn, macaan, dareere, viscous, oo leh dhadhan macaan diiran, oo badanaa loo yaqaan glycerin. Ku habboon falanqaynta xalka aqueous, jilicsanaanta, iwm. Waxaa lagu kala diri karaa biyo ah qayb kasta, iyo xalka ugu hooseeya ee glycerce-ka waxaa loo isticmaali karaa sida saliidda si ay u qoyso maqaarka. SORTOSCOL, Budada Fududcopic-ka cad ama budada crystallines, jajabyada ama granules, ur la'aan. Waxay leedahay howlo ka mid ah qoyaanka nuugista iyo haynta biyaha. Ku darista waxoogaa wax yar soosaarka xanjada xanjada iyo nacnaca ayaa cuntada ka ilaalin kara, ururinta hay'adda oo yareyn kartaa adkeynta oo ay ka ciyaaraan doorka ciidda. Glycerol iyo Sortol waa labadaba walxyo-biyo-ku-milma, kuwaas oo lagu qasin karo iyada oo ay weheliso qormooyinka unugyada biyaha-miyuusigga ah [23]. Waxaa loo isticmaali karaa kuwa wax balaastigga ah ee loo yaqaan 'cluelose'. Ka dib markii lagu daro, waxay horumarin karaan dabacsanaanta iyo ciribtirka fasaxa aflagaadada kaadida. (29). Guud ahaan, uruurinta xalka waa 2-5%, iyo xaddiga balastar-ka waa 10-20% unugyada unugyada unugyada. Haddii nuxurka ay caagadu aad u sarreeyaan, ifafaalaha ka yaraheeda ee fuuqbaxa ee isku dhaca ayaa ku dhici doona heerkul sare [30].

1.2 Isbeddelka isku-buuqa ee isku-duwaha ee hydroxypropyl methylcellosure filimka

Filimka biyaha-milmi-biyaha ayaa leh jilitaan biyo wanaagsan, laakiin lama filayo inuu si dhakhso ah u milimo marka loo isticmaalo munaasabadaha qaarkood, sida bacaha baakadaha abuur. Abuurkii waxaa lagu duudduubay filim biyo-ku-militari ah, oo kordhin kara heerka badbaadada ee abuurka. Waqtigaan, si loo ilaaliyo abuurka, lama filayo in filimku si dhakhso ah u milmi doono, laakiin filimka waa inuu marka hore ka ciyaari karaa saameyn biyo-haynta ah oo ku saabsan abuurka. Sidaa darteed, waxaa lagama maarmaan ah in la dheereeyo waqtiga biyaha-lagululey ee filimka. [21].

Sababta oo ah sababta ay ku jirto hyroxypropylylulose methylcelrellose ay leedahay culeys biyo ah oo wanaagsan qaab dhismeedka hydroxyl-ka ee loo yaqaan 'linkroxylplopyles' ee hydroxyplusplrcyls melecules meleculesphilis methylcellosure Yareeyn, taas oo yareynaysa jilicsanaanta biyaha ee biyaha ee hydroxyplopyllrcellesulose filimka, oo isku xirayaasha isku xirka ah ee ka dhexeeya @droxyl-ka iyo aldehydes ayaa abuuri kara dammaanad badan oo kiimiko ah, kaas oo sidoo kale hagaajin kara guryaha farsamada ee filimka illaa xad. Aldehydes-ka iskutallaabyada leh ee ku xiran hydroxypropylylcelrelouse waxaa ka mid ah glutaraldehyde, glutaldehyde, glutaldehyde, iwm. Waa nabadgelyo, in glutaraldehyde guud ahaan loo isticmaalo sida wakiilka isku xirka isku xirka ee anshaxa. Caddadka nooca noocan ah ee wakiilka isku xidhka xalka xalka ah guud ahaan waa 7 ilaa 10% culeyska ether. Heerkulka daweynta waa 0 illaa 30 ° C, oo waqtiguna waa 1 ~ 120 daqiiqo [31]. Fal-celinta iskutallaabta isku xirka ayaa loo baahan yahay in lagu qaado shuruudaha aashitada. Marka hore, aashitada aashitada ah ee 'inorgicylic-ka'. Aashitada loo adeegsado waxaa ka mid ah HCL, H2SO4, acetic acid, citric acid, iyo wixii la mid ah. Asiidhka iyo aldehyde sidoo kale waa lagu dari karaa isla waqtiga si loo sameeyo xalka uu ka dhigto falcelinta isku xirka iskuxirka ee xadka PH [33].

1.3 Guryaha antioxidative ee hydroxypropyl metylcellesulose filimyada

Hydroxypropylykyl'elrelose wuxuu hodan ku yahay kheyraadka, fududahay in la sameeyo filim, oo uu leeyahay saameyn wanaagsan oo cusub. Sida cuntada lagu keydiyo, waxay leedahay awood horumar weyn [34-36].

Zhuang Ronngyu [37] Waxaa loo adeegsaday hydroxypropylyl methylcelrellose (HPMC) oo lagu dahaadey filim, ka dibna ku keydiso 20 ° C 18 maalmood si ay u bartaan saamaynta ay ku leedahay adkeynta tamaandhada iyo midabka. Natiijooyinka ayaa muujinaya in adkaanta tamaandhada leh ee leh daboolka HPMC ay ka sarreyso kuwa aan lahayn dabool la'aan. Waxaa sidoo kale la cadeeyay in filimka HPMC la cuni karo uu dib u dhigi karo isbedelka midabka ee yaanyada casaan ilaa casaan marka lagu keydiyo 20 ℃.

[38] Wuxuu bartay saamaynta ku-abuurka hydroxypropylsulose (HPMC) Dareenka dahaadhka (hethocyanin synthesis iyo waxqabadka antioxidat ee "wuzhong" ee "Wuzhong" ee BAYS inta lagu jiro keydinta qabow. Natiijooyinka ayaa muujinaya in waxqabadka ka soo horjeeda ee Bayerry ee lagu daaweeyay filimka HPMC ee HPMC la wanaajiyey, oo heerka suuska inta lagu keydiyo ayaa la yareeyay, iyo saamaynta 5% filimka HPMC ayaa ugu fiicnaa.

Wang Kaikai et al. [39] Waxaa loo adeegsaday "wuzhong" ee Bayberry "ee maaddada imtixaanka si ay u bartaan saamaynta 'Ribroxyplinyplolose' 'HIOFLOVESYPLELOSLENT' ee 'POSTERTS' ee miro yar yar yar iyo miraha bayda lagu keydiyo inta lagu keydiyo 1 ℃. saamaynta waxqabadka. Natiijooyinka waxay muujiyeen in miro dhir udgoon ee 'riboflavin' ay ka waxtar badan tahay xaraashka feeraha ama daboolka HPMC, si wax ku ool ah hoos u dhigista heerka suuska miraha ee Badyberry inta lagu jiro kaydinta, oo ay ku sii dheereeyaan muddada kaydinta midhaha.

Sanadihii la soo dhaafay, dadku waxay leeyihiin shuruudo sare oo sareeya oo loogu talagalay badbaadada cuntada. Baarayaasha guriga iyo dibedda waxay si tartiib tartiib ah u beddeleen cilmi baaristooda diiradda saara cunnooyinka waxyaabaha lagu daro cuntada ee agabka baakadaha. Adigoo ku daraya ama ku buufin antioxidant-ka agabyada baakadaha, waxay yareyn karaan cuntada. Saamaynta heerka suuska ah [40]. Antioxidayaasha dabiiciga ah ayaa si aad ah uga walaacsan sababta oo ah nabadgelyadooda sare iyo saameynta caafimaad ee wanaagsan ee jirka bini aadamka [40,41].

Antioxidant of bamboo caleemaha bamboo (aob for gaagaaban) waa antioxidant dabiici ah oo leh caraf dabiici ah oo dabiici ah oo udgoon udgoon iyo madax xanuun biyo ah. Waxaa lagu taxay heerka Qaranka ee GB2760 waxaana wasaaradda caafimaadka uu ansixiyay inuu yahay antioxidant for cunnada dabiiciga ah. Waxaa sidoo kale loo isticmaali karaa sida cuntada lagu daro waxyaabaha hilibka lagu sameeyo, alaabada biyaha iyo cuntada la xayeysiiyay [42].

Qorrax Lina iwm. [42] Dib u eegay qaybaha ugu muhiimsan iyo guryaha ee antioxidayaasha caleenta caleenta ah waxayna soo bandhigtay arjiga ka hortagga antioxidayaasha caleen ee caleen ee caleenta. Ku darista 0.03% AOB ilaa majones cusub, saameynta antioxidant waa kuwa ugu cad waqtigan. Marka la barbar dhigo isla xaddiga antia playyfenol ee shaaha, saameynta antioxidant-ka ayaa iska cad inay ka fiican tahay tan polyphenols shaaha; Ku darista 150% biirka mg / L, guryaha antioxidant iyo xasilloonida kaydinta ee biirku si weyn ayaa loo kordhiyaa, biirkuna wuxuu ku habboon yahay jirka khamriga. Intii lagu hubinayaa in tayada asalka ah ee jirka khamriga, waxay sidoo kale kordhisaa caraf udgoon iyo dhadhan barafka ah ee bambo bambaanooyinka [43].

Marka la soo koobo, hydroxypropylyl methylcelrelolose waxay leedahay filim-filim wanaagsan oo qaab dhismeedka ah iyo waxqabadka wanaagsan. Sidoo kale waa wax cagaar ah oo sharaf leh, oo loo isticmaali karo filim baakado ah oo ku yaal duurka baakadaha [44-48]. Glycerol iyo Sortol waa labaduba agaasimaha biyaha-lagululeeyo. Ku darista Glycerol ama Sortol si loo wajaho xalka unugyada unugyada ee 'Mel-ka' waxay horumarin kartaa adkaanta 'hyroxypropyl methylcelrelolose metholcelrelose', taas oo ku kordhinaysa wareegga nasashada filimka [49-51]. Glutarardehyde waa jeermis-dile si caadi ah loo isticmaalo. Marka la barbar dhigo aldehydes kale, waa mid nabdoon, waxayna ku leedahay koox Qeyb-ka-dheer ee Molecule, oo xawaaraha iskutallaabta isku xirka iskutallaabta ayaa si dhakhso leh u dhakhso badan. Waxaa loo isticmaali karaa in wax laga beddelo iskutallaabta isku xirka ee ku saabsan hydroxypropyl filimka methylcelrelus. Waxay hagaajin kartaa xariiga biyaha ee filimka, si filimka loo isticmaali karo marar badan [52-55]. Ku darista bamboo caleen caleen ah oo ku daraya hydroxypropylylrcellerose filim si loo wanaajiyo astaamaha antioxidant ee hydroxypropulose filimka laguna ballaariyo baakadaha cuntada.

1.4 Soo-jeedinta mawduuca

Xaaladda cilmi baarista ee hadda jirta, filimada biyaha-milmi-biyaha ayaa inta badan ka kooban filimaanta PVA, filimada peo, ee Statech-Platch-Pluples Stupy. Sida qalabka ku saleysan Batroolka, PVA iyo POE waa ilo aan cusboonaysiin karin, geedi socodka wax soo saarka ee agabkooda ceyriinka ah ayaa laga yaabaa inay wasakheeyaan. In kasta oo Mareykanka, Japan iyo dalal kale ay ku taxeen inay yihiin walax aan sun ah, nabadgelyadeeda wali waxay u furan tahay su'aal. Labada neef-neefsashada iyo is-nuujinta labadaba waxay waxyeelo u leeyihiin jirka [8], oo laguma magacaabi karo kimistariga cagaaran oo dhammaystiran. Geedi socodka wax soo saarka ee istaarijka ku saleysan istaarijka-ku-saleysan-salka ku saleysan ee ku saleysan Sidaa darteed, xaaladaha badankood, waxay u baahan yihiin in lagu diyaariyo iyagoo isku darka leh waxyaabo kale sida PVA. Qiimaha isticmaalka ma sarreeyo. Sidaa darteed, waxay muhiimad weyn u tahay in la sameeyo wax cusub, oo la cusbooneysiin karo, oo la cusbooneysiin karo, oo ah baakadaha filim ka buuqa biyaha oo leh wax qabad aad u wanaagsan si kor loogu qaado ciladaha filimka biyaha ee hadda jira.

Hydroxypropylykylcellellase waa shey polymer dabiici ah, oo aan ahayn mid hodan ah kheyraadka, laakiin sidoo kale waa la cusbooneysiin karaa. Waxay leedahay culeys biyo ah oo wanaagsan iyo astaamo sameynta filim, waxayna leedahay xaaladaha diyaarinta filimada baakadaha biyaha-ku-milma. Sidaa darteed, warqaddani waxay ku talajirtaa inay diyaarsato nooc cusub oo ah filim ka buuqa biyaha biyaha lagu buufiyo ), wakiilka isku xirka iskuxirka (Glutaraldehyde), antioxidant (bamboo caleenta caleenta ah), oo ay u hagaajiyaan guryahooda, si ay u helaan guryo farsamo ahaan, guryaha indhaha, xaruuf biyo ah iyo astaamaha ka hortagga antioxidant. Metylcelrellose filimyada xirmada biyaha ee biyaha ayaa ahmiyad weyn u leh arjigiisa inay tahay sheyga filim ka buuqa biyaha biyaha.

1.5 Cilmi baarista

Tusmada cilmi baarista waa sida soo socota:

1) Filimka baakadaha biyaha ee HPMC-ka ee HPMC waxaa loo diyaariyey xalka qaab-dhismeedka filimka sameynta, iyo sifooyinka filimka ayaa lagu falanqeeyay si ay u bartaan saameynta dareeraha filimka ee 'Flivi' ee 'Fliven' iyo Foomka-Filimka Qaab-dhismeedka Qaab-dhismeedka Xirmooyinka Xirmooyinka biyaha ee HPMC.

2) In lagu barto saameynta Glycerol iyo Sortol Calaamadoodu ku yaalliin guryaha farsamada, silsiladaha biyaha iyo guryaha indhaha ee filimada baakadaha biyaha ee HPMC.

3) In lagu barto saameynta wakiilka xiidmaha ee Glutaraldehyde ee isku xirnaanta biyaha, guryaha farsamada iyo astaamaha indhaha ee filimaanta baakadaha biyaha ee HPMC.

4) Diyaarinta AOB / HPMC biyo-ku-xidhmada biyaha. Cadaadiska oksidaustan, jilitaanka biyaha, guryaha farsamada iyo guryaha indhaha ee filimka 'aOb / hpmc' ayaa la bartay.

CUTUBKA 2 Diyaarinta iyo Guryaha ee Hydroxypropyl by methyl clululose plulule-ka biyaha-ku-milma

2.1 Hordhac

Hydroxypropyl methylcelrellose waa mid ka dhalata dabiiciga ah ee dabiiciga ah. Waa wax aan sun ahayn, oo aan la cusbooneysiin, la cusbooneysiin karo, kimikal ahaan xasilloon, oo uu leeyahay isku-dhafan biyo oo wanaagsan iyo astaamaha sameynta filimka. Waa shey sawir-biyo-biyoodka ah oo suuragal ah.

Cutubkani wuxuu u isticmaali doonaa hydroxypropyl methylcelrellase maadaama sheyga ceyriinka ah si loogu diyaariyo hyroxypropyl chatchelsypellsyl-ka ah ee loo yaqaan 'plat' oo ay ku yeelato saamaynta dareeraha ah ee ka-hortagga ah ee ku saabsan fekerka-gelinta ee filimka, filimka, indhaha, iyo helitaanka guryaha-xabbadda. Guryaha qaylada ee filimka waxaa lagu gartaa raajo kaladuwan, iyo xoogga khafiifka ah, finanka nalka, transming-ka nalka, oo ah transming-ka khafiifka ah ee kahadalka ee 'platyroxyplus plat', oo lagu falanqeeyo tijaabada khafiifka ah, baaritaanka indhaha iyo heerka fadhiga biyaha.

2.2 Waaxda Tijaabada

2.2.1 Qalabka tijaabada ah iyo aaladaha

2.2.2 Diyaarinta Muujinta

1) Miisaankiisu yahay: miisaan qaddar cayiman oo ah hydroxypropyl methylrcellellase oo leh isku dheelitirka elektiroonigga ah.

2) Kala diridda: Ku dar miiska miisaanka ah ee miisaanka metroxylrcelrelosuse ee loo diyaariyey biyaha la diyaariyey, walaaq heerkulka caadiga ah ilaa ay si buuxda u milmaan muddo cayiman (ka-hortagga) si loo helo xoogaa uruurinta qaarkood. dareeraha xuubka xuubka. Waxaa lagu dejiyay 2%, 3%, 4%, 5% iyo 6%.

3) Abuuritaanka filimka Qalabka 'hydroxypropylpylpyl methylcelrellose kahada' 'Shucaaca' Shuctons 25-50 μm waa la diyaariyaa, filimka ayaa laga tirtirayaa oo lagu meeleeyaa sanduuqa qalajinta si loo isticmaalo. Feejignaanta filimada khafiifka ah ee heerkulka filim oo kala duwan (heerkulka inta lagu gudajiro qalajinta iyo sameynta filimka): ku duro xalka filimka ee heerkulka quraaradda ah (30 ~ 70 ° C) filimka lagu qalajiyey foornada hawo-dhexaadka ah. Feejignaanta hydroxypropyl methylcelrellose kahadaynta xirmada biyaha ee dhumucda ilaa 45 μm ayaa la diyaariyey, filimka waxaa loo diiday oo lagu meeleeyay sanduuqa qalajinta si loo isticmaalo. The Placexypropyl methylcelrelose methylcelrellose kahadalka biyaha-ku-milmada ah ayaa loo yaqaan filimka HPMC ee gaagaaban.

2.2.3 Cilmiga iyo cabirka waxqabadka

2.2.3.1.1 Raadinta xagal-xagal-wanaaga ah (XRD) Falanqaynta (XRD)

Ray-xagal-xagal-xagal-xagal kaladuwan (XRD) ayaa falanqayneysa xaalada crystallone ee walaxda heerka molikalalar. Raajada raajada ee nooca arl / xtra nooca ay soo saartay shirkadda Thermo arl ee Switzerland ayaa loo adeegsaday go'aanka. Shuruudaha cabbiraadda: Isha raajada ayaa ahaa ling-kα α α line (40kv, 40ma). Xagasha sawirka waa 0 ° illaa 80 ° (2θ). Xawaaraha Sawirka Xawaaraha 6 ° / Min.

2.2.3.32 Guryaha farsamada

Xooggaaga khafiifka ah iyo cidhiidhiga ah ee filimka waxaa loo isticmaalaa sidii shuruudaha loogu talagalay xukunka hantida farsamaynta, iyo xoogga khafiifka ah (xoogga khafiifka ah) waxaa loola jeedaa culeyska ugu badan ee caaga ah, oo cutubkuna waa MPA. Dood-siinta nasashada (oo jaba'inta u kala go'ay) waxaa loola jeedaa saamiga dalaga markii filimka uu u jabay dhererka asalka ah, oo lagu muujiyey%. Adigoo adeegsanaya aaladda (5943) Nooca yar ee tijaabada ah ee tijaabada ah ee tijaabada ah ee aaladda (Shanghai) ee habka tijaabada ee GSETS, oo ah Shuruudaha Imtixaanka Geerida ee Guryaha Tsifile ee Guryaha Tsifile ee Guryaha TS130, 50% SHURUUDAHA IYO KHUDBADAHA ISTICMAALKA IYO DUGSIGII LABAAD.

2.2.3.3 Guryaha indhaha

Guryaha indhaha ayaa ah tilmaame muhiim u ah daahfurnaanta filimada baakadaha, oo inta badan ay ku jiraan maleega iyo harooyinka filimka. Faafinta iyo harooyinka filimada ayaa lagu cabiray iyadoo la adeegsanayo tijaabada wadnaha. Ka soo qaado tijaabo tijaabo ah oo leh dusha nadiifka ah oo aan lahayn wax xanaaq ah, si tartiib ah ugu dhig safka imtixaanka, ku hagaaji koob cagaaran, oo waxaad cadaysaa khafiifinta iftiinka iyo haze ee filimka heerkulka qolka (25 ° C iyo 50% r iyo 50% rh). Shaybaarka waxaa la tijaabiyaa 3 jeer oo celceliska qiimaha ayaa la qaadayaa.

2.2.3.44 Xoolaha Xoolaha

Iska yaree 30mm × 30mm 30m ah oo dhumuc weyn leh qiyaastii Muunad kasta waxaa lagu cabiray 3 jeer oo celcelis ahaan qiimaha la qaatay, oo cutubkuna wuxuu ahaa min.

2.2.4 Xogta Xogta

Xogta tijaabada ah waxaa laga baaraandegay Excel waxayna ku qasbeen software asal ahaan.

2.3 Natiijooyinka iyo wada hadalka

2.3.1.1.1 XRD Qaababka filimada khafiifka ah ee HPMC ee ku yaal filimka xallinta filimka oo kale

Jaantus2.1 XRD ee filimada HPMC ee ku xusan waxyaabo kala duwan oo HP ah

Rayr-xagal-xagal-xagal-xagal ah ayaa ah falanqaynta xaalada xaalada ee maandooriyaha ee walxaha molikalalar. Jaanka Waxaa jira laba meelood oo kala duwan [57-59] (u dhow 9.5 ° iyo 20.4 °) filimka HPMC ee sawirka. Waxaa lagu arki karaa tirada in la kordhiyo feejignaanta HPMC, ee ugu sarreeya filimka HPMC ee ku dhawaad ​​9.5 ° iyo 20.4 ° ayaa marka hore la wanaajiyaa. Ka dibna daciifiyay, heerka loo habeeyo qaab-dhismeedka molikalalar (qabanqaabada la dalbaday) ayaa markii ugu horreysay kordhay ka dibna hoos u dhacay. Marka feejignaantu ay tahay 5%, hab-hakinka nidaamsan ee moleekules-ka HPMC waa mid aan fiicnayn. Sababta ifafaale kor ku xusan ayaa laga yaabaa inay tahay in kororka feejignaanta HPMC, tirada cunsuriyadda Nuclei ee xalka filimka ay sii kordhayaan, sidaas darteedna u sameynta qaab-dhismeedka mpm si joogto ah. Marka feejignaanta HPMC ay ka badan tahay 5%, heerka ugu sarreeya ee XRD ee filimka ayaa daciifinaya. Marka laga eego aragtida silsiladda molikalar, markii feejignaanta HPMC ay aad u weyn tahay, aragtida HPMC xalka xalka filimka ayaa aad u sarreeya, taasoo ka dhigeysa in waqtiga loo habeeyo, sidaa darteed sababi karo in heerka lagu dalbanayo filimada filimka HPMC.

2.3.1.2 Hantida farsamada ee filimada khafiifka ah ee HPMC hoostooda ku xusan isugeynta xalka filimka oo kale.

Xooggaaga khafiifka ah iyo cidhiidhiga ah ee filimka waxaa loo isticmaalaa sidii shuruudaha loogu talagalay xukunka hantida farsamada, iyo xoogga khafiifka ah ay ka dhigan tahay walaaca fekerka marka filimka labiska labiska ku qoro. Qulqulka fasaxa ayaa ah saamiga barakaca ee dhererka asalka filimka. Cabbirka sifooyinka farsamada ee filimka ayaa ku xukumi kara arjigiisa meelaha qaar.

Jaantus2.2 Saamaynta ku saabsan waxyaabaha kaladuwan ee HPMC ee ku saabsan guryaha farsamada ee filimada HPMC

Laga bilaabo Jaantus. Markii uu uruursanaanta xalka ahi waa 5%, sifooyinka farsamada ee filimada HPMC ayaa ka fiican. Tani waa sababta oo ah marka filimka loo yaqaan 'Filimku' uu hooseeyo, xalka viscosity waa mid liidata, sidaa darteed awooda moleekulka ayaa loo habeyn karaa si habsami leh, sidaa darteed awoodda crystallies ee filimka ayaa ah mid liita; Marka filimka loo habeeyo dareeraha dareeraha uu yahay 5%, guryaha farsamada ayaa gaaraya qiimaha ugu habboon; Iyada oo loo fiirsanayo dareeraha filimka 'filim-filimku uu sii kordhayo, tuurista iyo kala-soocidda xadka si aan caadi ahayn, oo ka dhalata in ka badan oo kacsan [60], oo ay ka dhasheen yareynta astaamaha farsamada ee filimada farsamada ee HPMC. Sidaa darteed, uruurinta 5% HIPMC Filim Foomka Filimka ee HPMC ayaa ah kuwa ugu haboon. Waxqabadka filimka la helay ayaa sidoo kale ka fiican.

2.3.1.3 Sifooyinka indhaha ee filimada khafiifka ah ee HPMC hoostooda ku xusan filimka xalka filimka oo kale

Filimyada baakadaha, majalada khafiifka ah iyo haragga haragga ayaa ah cabbirro muhiim ah oo muujinaya daahfurnaanta filimka. Jaanka Waxaa lagu arki karaa tirada in la kordhiyo uruurinta xallinta filimka 'HPMC', goynta falka filimka 'HPMC' tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib tartiib ah ayuu usii ahaa.

Jaantus2.3 Saamaynta ay ku jiraan waxyaabo kala duwan oo HPMC ah oo ku saabsan hantida indhaha ee filimada HPMC

Waxaa jira laba sababood oo ugu waaweyn: Marka hore, laga soo qaado aragtida tirooyinka lambarka ee wejiga kala firidhsan, marka feejignaantu ay hooseyso, tiradu waxay leedahay saameyn ugu weyn ee guryaha indhaha ku haya ee maaddada [61]. Sidaa darteed, iyadoo kororka uruurinta xalka filimka 'HPMC', cufnaanta filimka ayaa la dhimay. Khafiifinta khafiifka ah ayaa si weyn hoos ugu dhacay, oo haraggana si weyn ayuu usii kordhay. Midda labaad, laga soo bilaabo falanqaynta geedi socodka sameynta filimka, waxaa laga yaabaa inay tahay sababta oo ah filimka waxaa sameeyay xalka xalka qaabka filimka qaab-dhismeedka filimka. Kordhinta adkaanta adkaanta ayaa horseedaysa in la dhimo faseexalka dusha sare ee filimka iyo hoos u dhaca guryaha indhaha ee filimka HPMC.

2.3.1.4 Xoolaha biyaha ee filimada khafiifka ah ee HPMC ee hoos imanaya isku-darka dareeraha filimka oo kale

Xarafta biyaha ee filimada biyaha-militariga ah waxay la xiriirtaa feejignaantooda filimkooda. Iska yaree 30mm × 303mm vizong oo lagu sameeyay filim kala duwan oo loo habeeyo, kuna calaamadi filimka "+" si loo cabbiro waqtiga filimka si uu u baabaxo. Haddii filimku ku duubto ama ulaha darbiyada khaanadda, dib u noqo. Jaantus 2.4 waa jaangooyooyinka isbeddelka ee xoolaha biyaha ee filimada HPMC ee ku xusan ururinta dareeraha filimka oo kala duwan. Waxaa lagu arki karaa tirada in la kordhiyo isku-darka dareeraha filimka, waqtiga biyaha-lagu milmay ee filimada HPMC ay sii dheeraato, taas oo muujineysa in xoolaha biyaha ee filimada HPMC ay yaraato. Waxaa la cayimay in sababtu ay tahay in la kordhiyo kor u qaadida xalka filimka '' HPMC ', aragtida xalka xalka, iyo xoogga isku-darka ah, taasoo dhalisay daciifnimada filimka ee filimka HPMC ee biyaha iyo hoos udhaca xoolaha biyaha.

Jaantiiraadka

2.3.2 Saamaynta Heerkulka Samaynta Filimka ee Filimada Khafiifka ah ee HPMC

2.3.2.2.1 XRD Qaababka filimada khafiifka ah ee HPMC ee filim kala duwan oo lagu sameeyo heerkulka

Jaantus2.5 XRD ee filimada HPMC ee ku xusan heerkulka qaabka filim oo kala duwan

Jaantus 2.5 wuxuu muujinayaa qaababka XRD ee filimada khafiifka ah ee HPMC ee filim kala duwan oo lagu sameeyo heerkulka. Laba meelood oo kala duwan oo ah 9.5 ° iyo 20.4 ° ayaa loo falanqeeyay filimka HPMC. Marka laga eego aragtida xooga badan ee ugu sarreeya ee heerkulka sameynta filimka, ee ugu sarreeya ee ugu sarreeya ee labada meelood ee ay kordheen ka dib, iyo awoodda crystalliant-ka ayaa markii hore hoos u dhacday ka dibna uu yaraaday. Marka heerkulka qaab-dhismeedka filimka uu ahaa 50 ° C, habka loo amro ee moleekuleyaasha HPMC ee ka imanaya aragtida saameynta ay ku leedahay saamaynta heerkulka, iyadoo qaboojinta xalka nuclei uu yar yahay, iyo crystalliation waa adag tahay; Sida heerkulka qaab-dhismeedka filimku si tartiib tartiib ah u kordhayo, heerka nuc-ka, dhaqdhaqaaqa silsiladda molikalal si fudud ayaa loo habeeyaa si habsami leh, sidaa darteed crystallitions-ka ayaa lagu sameyn doonaa qiimaha ugu badan heerkulka qaarkood; Haddii heerkulka qaab-dhismeedka filimka uu aad u sarreeyo, dhaqdhaqaaqa molikalar waa mid aad u dagaal badan, abuuritaanka nukeynta nuktarka waa mid hooseysa oo ay adag tahay in la sameeyo kiristaan ​​[62,63]. Sidaa daraadeed, croupstallity of filimada HPMC wuxuu sii kordhayaa marka hore ka dibna wuxuu ku yaraanayaa kororka heerkulka abuurka filimka.

2.3.2.2 Guryaha farsamada ee filimada khafiifka ah ee HPMC ee filim kala duwan oo ku saabsan heerkulka

Isbedelka heerkulka qaab-dhismeedka filimka wuxuu lahaan doonaa heer gaar ah oo saameyn ku leh guryaha farsamada ee filimka. Jaanka Isla mar ahaantaana, waxay muujisay isbeddel ku sii kordhaya marka hore ka dibna yareynta. Marka heerkulka qaabka filimka uu ahaa 50 ° C, xoogga khafiifka ah iyo cidhifyada nasashada filimka HPMC ee Filimka HPMC ayaa gaadhay qiimayaasha ugu badan, kuwaas oo ahaa 116 MPA iyo 32%, siday u kala horreeyaan.

Jaantus2.6 Saamaynta filimka sameynta heerkulka ku saabsan astaamaha farsamada ee filimada HPMC

Marka laga eego aragtida qaab-dhismeedka molika, sida ugu weyn ee hab-hareynta molakules, sida ugu wanaagsan ee loo yaqaan 'xoogga jilicsan [64]. Laga soo bilaabo Jaangada. Marka heerkulka samaynta filimku uu yahay 50 ° C, heerka ugu weyn ee nidaamka la dalbaday waa kan ugu weyn, sidaa darteed xoogga caagga ah ee filimada HPMC marka hore ay sii kordhayaan ka dibna waxay ka dhigeysaa kororka heerkulka filimka, iyo qiimaha ugu badan ayaa ka muuqda heerkulka samaynta filimka ee 50 ℃. Qulqulka nasashada ayaa muujinaya isbeddel ku saabsan sii kordhaya marka hore ka dibna yareynta. Sababta ayaa laga yaabaa inay tahay in ay la socoto heerkulka, hab-haboonada habsamida ee moleekules marka hore kordhayo ka dibna yaraaday qaab-dhismeedka cryststalline-ka ayaa lagu kala firdhiyey matrix-ka promcrer-ka ah ee aanta lahayn. Matrix, qaab-dhismeedka isku xidhka jirka ayaa la sameeyay, kaas oo ka ciyaara kaalin gaar ah oo adag [65], taasoo ay ku dhiirrigelinayaan dalagga kala-baxa filimka HPMC si ay ugu muuqato heerkulka samaynta filimka ee 50 ° C.

2.3.2.3 Guryaha indhaha ee filimada HPMC ee filim kala duwan oo ku saabsan heerkulka

Jaantus 2.7 waa qalooca isbedelka ee guryaha indhaha ee filimada HPMC ee filim kala duwan oo ku saabsan heerkulka. Waxaa lagu arki karaa tirada kororka heerkulka filimka, goynta filimka 'Filimka', goynta filimka HPMC si tartiib tartiib ah ayuu u kordhaa, oo si tartiib tartiib ah u yaraaday si tartiib tartiib ah oo si tartiib tartiib ah filimka HPMC si tartiib tartiib ah ayuu u fiicnaanayaa.

Jaantus2.7 Saamaynta filimka sameynta heerkulka ee hantida indhaha ee HPMC

Marka loo eego saameynta kuleylka iyo moleekulada biyaha ee filimka [66], marka heerkulku hooseeyo, moleeku wuxuu ka dhex jiraa hpmc qaab biyo ah, laakiin xaddiga xadkan ayaa si tartiib tartiib ah uga fikiraya, oo HPMC waxay ku jirtaa gobolka dhalada. Qulqulka foomamka filimka ee HPMC, ka dibna ku firdhineysa godadka ka dib irbad irbad-haynta khafiifka ah [67], si iftiinka loo tallaalaa filimka ayaa hooseeya; Maaddaama heerkulku kordho, qaybaha molikalabka ee HPMC ee HPMC ay bilaabaan, godadka la sameeyo ka dib marka ay ka buuxsamaan in ay si tartiib tartiib ah u yareeyaan, sidaa darteed iftiinka ayaa kor u kacaya iftiinka filimka oo sii kordhaya.

2.3.2.4.4 Xoolaha xoolaha ee filimada HPMC ee filim kala duwan oo ku saabsan heerkulka

Jaantus 2.8 wuxuu muujinayaa qarashka fadhiga biyaha ee filimada HPMC ee filim filim oo kala duwan oo lagu sameeyo heerkulka. Waxaa lagu arki karaa tirada xaga xaga xaga ee loo yaqaan 'Sonups' Iyada oo kororka heerkulka qaab-dhismeedka filimka, heerka uumiga ee moleekulka biyaha iyo heerka gelitaanka ayaa la dejinayaa, kala-sooca miraha ee dusha sare ee filimka waa cufan, taas oo ku adkaynaysa moleekuleyaasha biyaha si ay u dhex galaan molecules-ka HPMC. Xoolaha biyaha ayaa sidoo kale la dhimay.

Jaantus2.8 Saamaynta filimka sameynta heerkulka biyaha ee xaruushida biyaha ee filimka HPMC

2.4 Soo koobid cutubkan

Cutubkan, hydroxypropyl methylcelrellase waxaa loo istcimaalaa sida ashyaa'da ceyriinka ah si loogu diyaariyo filimka baakadaha biyaha ee HPMC oo ay ku jirto xalka habeynta filimka qaab-dhismeedka filimka. Crystallillonity ee filimka HPMC ee HPMC waxaa falanqayn jiray XRD kala-duwanaanta XRD; Sifooyinka farsamada ee kahadalka ee xirmooyinka ee 'HPMC biyo-ku-xidhka' HPMC 'ayaa la tijaabiyey oo ay falanqeeyeen mashiinka tijaabada ee Tensel-Entronile-Encenile-ka Elektaroonigga ah, oo sifooyinka indhaha ee filimka HPMC waxaa lagu falanqeeyey tijaabada dareeraha ee HIPS. Waqtiga kala diridda biyaha (waqtiga sadafadda biyaha) waxaa loo isticmaalaa in lagu falanqeeyo jilitaanka biyaha. Gunaanadyada soo socda waxaa laga soo qaatay cilmi-baarista kor ku xusan:

1) Guryaha farsamada ee filimada 'HPMC' ayaa markii ugu horreysay kordhay ka dibna ay hoos ugu dhacday kororka uruurinta xalka filimka-filimka, oo ay marka hore hoos u dhacday ka dibna ay hoos ugu dhacday kororka heerkulka abuurka filimka. Markii ay uruurineyso xalka qaab-dhismeedka filimka ee HPMC wuxuu ahaa 5% iyo heerkulka qaab-dhismeedka filimka wuxuu ahaa 50 ° C, sifooyinka farsamada ee filimka ayaa wanaagsan. Waqtigaan, xoogga khafiifka ah waa qiyaastii 116mpa, oo dalagguna waa qiyaastii 31%;

2) Hantida indhaha ee filimada HPMC waxay hoos udhaceysaa kororka uruurinta xalka filimka-filimka, oo si tartiib tartiib ah loo kordhiyo kororka heerkulka abuurka filimka; si kooban u tixgeli in ururinta xalka qaab-dhismeedka filimka inuusan ka badneyn 5%, heerkulka abuurka filimka waa inuusan ka badneyn 50 ° C

3) Xoolaha xoolaha ee filimada 'HPMC' waxay muujiyeen isbeddel hoos u dhac ah oo kor u kacaya kororka uruurinta xalka filimka iyo kordhinta heerkulka abuurka filimka. Marka ay uruurineyso 5% HIPMC Filimka Filimka ee HPMC iyo heerkulka qaab-dhismeedka filimka ee 50 ° C ayaa la isticmaalay, waqtiga biyaha lagu diro ee filimka wuxuu ahaa 55 daqiiqo.

Cutubka 3 Saameynta

3.1 Hordhac

Sida nooc cusub oo polymer ah oo dabiici ah oo dabiici ah Hydroxypropyl methylcelrellose waa mid ka dhalata dabiiciga ah ee dabiiciga ah. Waa wax aan sun ahayn, oo aan wasakheyn, la cusbooneysiin karo, kimikal ahaan deggan, oo leh guryo wanaagsan. Biyaha-milmi-ku-dhiska iyo filimka sameynta, waa sheyga filimka filimka biyaha ee biyaha lagu milmi karo.

Cutubka hore ayaa ka wada hadlay diyaarinta filimka baakadaha biyaha ee HPMC iyadoo loo adeegsanayo hydroxypropyl methylrcellellase sida sheyga ceyriinka ah ee lagu sameeyo uruurinta filimka, iyo heerkulka qaab-dhismeedka filimka iyo qaab-dhismeedka 'hydroxypropyl methylcellerose pluluch'. saamaynta waxqabadka. Natiijooyinka ayaa muujinaya in xoogga khasabka ah ee filimka uu yahay 116MPA oo ku-meel-gaarka ah ee fasaxa uu yahay 31% oo hoos imanaya xaaladaha ugu habboon iyo xaaladaha habraaca. Axwaha filimada noocan oo kale ah ayaa liidata codsiyada qaarkood waxayna u baahan tahay horumar dheeraad ah.

Cutubkan, hydroxypropylylrcelrelose wali waxaa loo isticmaalaa sida shey ceyriin ah, oo filimka baakadaha biyaha-biyaha-milmiyeedka waxaa lagu diyaariyey xalka qaabka filimka sameynta. , Clortacting nasashada), guryaha indhaha ku dhaca (transminge, harade) iyo salaan biyo ah.

3.2 Waaxda Tijaabada

3.2.1 Qalabka tijaabada ah iyo aaladaha

Shaxda 3.1 Qalabka tijaabada iyo faahfaahinta

Shaxda 3.2 Qalabka Tijaabada ah iyo faahfaahinta

3.2.2 Sanad muunad ah

1) Miisaankiisu yahay: miisaan qaddar cayiman oo ah hydroxypropylylrcelrelose (5%) iyo sartotl) iyo saritlol (0.15%, 0.15%, 0.25%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.35%, 0.45%

2) Kala diridda: Ku dar miiska miisaanka ah ee miisaamay methylrcellellase ee loo diyaariyey biyaha la diyaariyey, walaaq heerkulka caadiga ah iyo cadaadiska ka dibna ku dar glycel ama sirtol ee jajabyo badan oo kaladuwan. In lagu gudajiro hydroxypropyll xalka, walaaq muddo ah si aad si siman isugu qasto, oo u oggolow inay u taagan tahay 5 daqiiqo (dayactir) si loo helo xoogaa uruurinta dareeraha filimka.

3) Sameynta filimka: Ku duri dareeraha filimka-filimka ah oo ku shub weelka dhalada ah oo ku tuur filim, ha u istaago foornada qaraxu inuu qalajiyo oo uu filim ku sameeyo qafiif ah oo leh 45 μm. Ka dib filimka lagu meeleeyo sanduuqa qalajinta ee loo isticmaalo.

3.2.3 Cilmi-yaqaannada iyo Tijaabada Waxqabadka

3.2.3.1 NABADGELYADA FARSAMADA EE SPEROSCOPY (FT-IR)

Informat offroscopy-ka (Ftiir) waa hab awood badan oo lagu garto kooxaha waxqabadka ee kujira qaab dhismeedka molika iyo si loo garto kooxaha waxqabadka. Caqabadaha ka soo baxa ee ka soo baxa ee filimka baakadaha ee HPMC waxaa lagu cabiray iyadoo la adeegsanayo Nicolet 5700 af-soo-galka ee Spectrometer-ka oo ay soo saartay shirkadda Thermolectric Shirkadda. Qaabka filimka khafiifka ah ayaa loo adeegsaday tijaabadan, tirada iskaanka ah waxay ahayd 500-4000 cm-1, iyo tirada sc-1, filimada muujinta waxay ku engegeen foornada qalalan 50 ° C 24 h oo loogu talagalay spectoscopy-ka.

3.2.3.22 Raajo-xagal-xagal-xagal-wanaaga ah (XRD) (XRD) oo lamid ah 2.2.3.1

3.2.3.3 Go'aan ka gaarista guryaha farsamada

Xooggaaga gorgorka ah iyo cidhiidhiga fasaxa filimka waxaa loo isticmaalaa sidii cabirro lagu gardaro hantida farsamada. Qulqulka fasaxa ayaa ah saamiga barakaca ee dhererka asalka ah markii filimka la jabiyo,%. Isticmaalka aaladda (5943) Midab-goynta Tensile ee Univerl ee Turnaanta Turnile ee Turnile ee Tartanka (Shanghai) Qalabka tijaabada ah ee GS133022-92 Xaaladaha 25%, oo ah rnjess, oo leh dusha sare, oo dusha sare ah oo aan ciladin lahayn.

3.2.3.3 Go'aan ka gaarista guryaha indhaha: la mid ah 2.2.3.3

3.2.3.5 Go'aaminta Xoogga Xoolaha

Iska yaree 30mm × 30mm 30m ah oo dhumuc weyn leh qiyaastii Muunad kasta waxaa lagu cabiray 3 jeer oo celcelis ahaan qiimaha la qaatay, oo cutubkuna wuxuu ahaa min.

3.2.4 Xogta xogta

Xogta tijaabada ah waxaa laga baaraandegay Excel, oo garaafkuna wuxuu soo jiiday softiweer asal ah.

3.3 Natiijooyinka iyo wada hadalka

3.3.1 Saameynta Glycerol iyo Sortol on Infrated nuugista cabitaannada aflagaadada ee filimada HPMC

(a) glycerol (b) sirtol

Jaantus3.1 FT-IR ee filimada HPMC ee hoos timaada Glycel ama SorritloLum Producrat

Informat offroscopy-ka (Ftiir) waa hab awood badan oo lagu garto kooxaha waxqabadka ee kujira qaab dhismeedka molika iyo si loo garto kooxaha waxqabadka. Jaantus 3.1 wuxuu muujinayaa in la soo koobay filimka 'HPMC' ee filimada HPMC oo leh Glycerol iyo SorTol SORTTOL. Waxaa lagu arki karaa tirada in dabeecadda lafaha qalqal-galka ah ee filimada HPMC ay inta badan ku jiraan labada gobol: 2600 ~ 37CCM-1 [[57-59], 3418cm-1

Xadhiga soo nuugista ee u dhow waxaa keena gariirka fidinta debaajiga ee Oh, 2935CM-1 waa heerka ugu sarreeya ee -ch2, 1050CM-1 waa in-ka-soo-nooleyaasha 'hyroxyl', iyo 1657cm-1 waa heerka ugu sarreeya ee kooxda hydroxypropyl. Kordhinta ugu sarreysa ee kooxda hydroxyl ee gariirka fidinta qaab dhismeedka, 945cm-1 waa cabaadka galka ah ee gacabka ah -ch3 [69]. Kordhinta buufintu waa 1454cm-1, 1373cm-1, 1315CM-1 iyo 945CM-1 waxaa loo xilsaaray gariirrada asymmetric,-galka-furenimada, ee diyaaradda, ee-diyaaradda iyo ka-tagida qoryaha diyaaradda-ka-baxa-18]. Ka dib markii lagula dhaqmaa, majiro kor-galyo cusub oo ka soo muuqday muuqaalka shaashadda ee filimka, taasoo muujineysa in HPMC aysan mamin isbedelo lama huraan ah, taasi waa, balastar-ka ma burburin qaab dhismeedka. Iyada oo lagu daro Glycerol, oo gariirka socodka ah ee sare ee 3418cmm-1 ee Filimka HPMC ee HPMC-ka ah ee 1650CM-1, iyo -Corocty ee kooxaha aasaasiga ah iyo kuwa hey'yada ah ee ku jira ayaa daciifa; Iyada oo lagu daro SORTTOL ee filimka HPMC, The -OH oo fidsan gariirkii ugu sarreysay 3418cm-1 daciif ah, iyo ka-hortagga salka ugu jira 1657cm-1 daciif ah. . Isbedelada ugu sarreeya ee ka-baxayaasha ah waxaa sababa waxyeelo soosaarid ah iyo isku xirka hydrogen-ka-dhexgalka, kaas oo iyaga ka dhigaya inay ku beddelaan guutada-ku xigta-iyo -Hh2. Sababta oo ah yar yar, galinta maadooyinka molikaulabka waxay caqabad ku tahay sameynta dammaanadda hydrogen-ka-dhex-dhexaadinta, sidaa darteed xoogga khafiifka ah ee filimka caagga ah ayaa hoos u dhaca [70].

3.3.2 saamaynta glycerol iyo sortol on qaababka XRD ee filimada HPMC

(a) glycerol (b) sirtol

Jaantus3.2 XRD ee filimada HPMC ee hoos timaada Glycel ama SortroLum Furras

Ray-xagal-xagal-xagal-xagal-kala-sooca (XRD) wuxuu falanqeeyaa xaalada qasaradda ee walxaha ee maandooriyaha ee heerka molikalalar. Raajada raajada ee nooca arl / xtra nooca ay soo saartay shirkadda Thermo arl ee Switzerland ayaa loo adeegsaday go'aanka. Jaantus 3.2 waa qaababka XRD ee filimada HPMC oo leh isugeyn kala duwan oo Glycerol iyo Sortol. Iyada oo lagu daro Glycerol, xoogga xoogga kaladuwan ee 9.5 ° iyo 20.4 ° labadiinaba daciif; Marka lagu daro sartol, marka lacagta lagu daro ay ahayd 0.15%, ugu sarreysay ugu sarreysay, iyo ugu sarreysay, laakiin wadarta xoojinta ugu sarreysa ayaa ka hooseysay tiirarka 'HPMC' oo aan lahayn SORTOM la'aan. Iyada oo ay weheliso joogtada ah ee sirtol, ugu sarreysaa ugu sarreysa ee 9.5 ° mar labaad daciifa, iyo ugu sarreeya ee ugu sarreeya ee 20.4 ° si weyn u beddelin. Tani waa sababta oo ah ku darista unugyada yaryar ee glycel iyo sortol waxay khalkhal gelisaa qaab-dhismeedka si habsami leh ee silsiladaha molikular waxayna baabi'isaa qaabdhismeedka asalka ah ee asalka ah, taasoo yareynaysa crystallial-ka filimka. Waxaa laga arki karaa tirada glycelceerku ay saameyn weyn ku leedahay crystallition ee filimada HPMC, taasoo muujineysa in glycerol iyo HPMC ay leeyihiin iswaafajin wanaagsan, halka Sormc iyo HPMC ay leeyihiin iswaafajin liidata. Laga soo bilaabo falanqaynta qaab-dhismeedka ee balaastikada, siortrol waxay leedahay qaab galka sonkorta oo la mid ah kan unugyada caleenta, taasoo dhalisay isdhaafsi daciif ah oo udhaxeysa molecules sortoll iyo molecules-yada dhiigga, sidaa darteed waxay saameyn yar ku leedahay choleecaling-ka-hoolka.

[48].

3.3.3 Saameynta Glycerol iyo Sortol ee ku saabsan guryaha farsamada ee filimada HPMC

Xooggaaga khafiifka ah iyo cirifka fasaxa ee filimka waxaa loo isticmaalaa sidii cabirro lagu xukumo hantida farsamada, iyo cabbiraadda guryaha farsamada ayaa ku xukumi kara arjigiisa meelaha qaarkood. Jaantus 3.3 wuxuu muujinayaa isbedelka xoogga khasabka ah iyo cirifka fasaxa aflaanta ee HPMC ka dib markii uu ku daro kuwa caagga ah.

Jaantus3.3 Saamaynta Glycel ama Sorritrolon on Qalabka Mashiinka ee Flives HPMC

Waxaa lagu arki karaa Jaantuska 3.3 (a) Marka lagu daro Glycerol, oo ka-baxa nasashada filimka HPMC ee ugu horreeya ee HPMC ayaa sii kordhaya ka dibna hoos u dhaca, ka dibna si tartiib tartiib ah ayuu u sii kordhayaa ka dibna wuu sii yaraanayaa. Qulqulka jabinta filimka HPMC ee ugu horeeya ee HPMC ayaa marka hore kordhay ka dibna uu hoos u dhacay, sababtoo ah Glycerol waxay leedahay kooxo kacsan oo ka-hortaga ah, kaas oo ka dhigaya in mololules-ka biyaha iyo biyaha ay leeyihiin, sidaa darteed hagaajinta dabacsanaanta filimka. Iyada oo kordhinta isdaba joogga Glycrol, dalaggii uu ka jabay filimka HPMC ee HPMC ayaa hoos u dhaca, taas oo ah Glycerol-ka ayaa hoos u dhacaya, oo filimku uu u nugul yahay marka filimka uu ka dhinto, taasoo yareynaysa wareejinta filimka. Sababta hoos u dhaca deg-degga ah ee xoogga khafiifka ah waa: Ku darista moleekuleyaasha yaryar ee glycel-ka Glycel ayaa ka dhex dhacaya silsiladaha miraha ee HPMC, waxay yareysaa awoodda is-dhexgalka ee u dhexeeya macromoleeces, waxayna yareysaa xoogga qalloocan ee filimka; Awoodda jilicsan ee kor u kaca yar, marka laga eego aragtida silsiladda molikalal, glycel ku habboon ee miraha miraha molicular ilaa xad, waxay kor u qaadaa abaabulka silsiladaha miraha polymer-ka, waxayna ka dhigeysaa xoogga filimka wax yar; Si kastaba ha noqotee, marka ay jiraan wax aad u badan glycerol, silsilado molikalar ah ayaa loo habeeyey isla waqtiga loo habeeyey qaabka hab-dhaqanka, iyo sicirka qaab-dhismeedka uu ka sarreeyo sidan oo kale, taas oo dhalisay in si tartiib tartiib ah loo eego filimka HPMC. Maaddaama saameynta adag ee ay tahay qaddarka xoogga khasabka ah ee filimka HPMC, qadarka Glycel ayaa lagu daray inaysan aheyn wax aad u badan.

Sida ka muuqata Jaantuska 3.3 (b), oo lagu daro sartol, cidhifyada nasashada ee filimka HPMC ee 'HPMC' ayaa marka hore kordhay ka dibna uu yaraaday. Marka qadarka sixirku uu ahaa 0.15%, wareegga nasashada ee filimka HPMC ee HPMC wuxuu gaadhay 45%, ka dibna dalaggii uu jabay filimka ayaa si tartiib tartiib ah u yaraaday. Awooda khafiifka ah ayaa si dhakhso ah u yareynaysa, ka dibna waxay is bedbeddelaysaa ku dhawaad ​​50mp oo leh wada-noolaanshaha si loo kordhiyo ee Saaftol. Waxaa la arki karaa in markii xaddiga sartotl lagu daray ay tahay 0.15%, saameynta qalalaase ee ugu fiican. Tani waa sababta oo ah isugeynta moleekuleyaasha yaryar ee sortoltolka ayaa khalkhal gelinaya qaabka caadiga ah ee silsiladaha miraha, oo ah in moleekuluhu ay fududahay in la kala baxo, sidaa darteed cidhifyada jaban filimka ayaa kordhaya oo hoos u dhaca xoogga. Maaddaama cadadka sixirku sii kordhayo, qulqulka fasaxa filimka mar labaad uu hoos u dhacay, maxaa yeelay moleekul yar oo u dhexeeya dhimista mucromoleececules iyo hoos udhaca ee ku dhaca mucjisooyinka ku baxa filimka.

Isbarbardhiga saameynta saamiga ah ee glycerol iyo sobrol on filimada HPMC, oo ku daraya 0.15% Glycerol waxay kordhin kartaa dalagga kala jabay filimka ilaa 50%; Intii lagu daray 0.15% SORTTOL waxay kordhin kartaa oo keliya dalaga nasashada filimka sicirka uu gaaro 45%. Xoog xoog badan ayaa hoos u dhacday, oo hoos udhaca ayaa ka yaraa markii Glycel lagu daray. Waxaa la arki karaa in saameynta qalalaase ee glycel on filimka HPMC uu ka fiican yahay kan sixir sixir.

3.3.4 saamaynta glycerol iyo sobrol on guryaha indhaha ee filimada HPMC

(a) glycerol (b) sirtol

Jaantus3.4 Saamaynta Glycel ama Sorritoloumon hantida indhaha ee filimada HPMC

Khafiifinta khafiifka ah iyo haze waa cabbirro muhiim u ah hufnaanta filimka baakadaha. Muuqaalka iyo caddeynta alaabada baakadu waxay ku xirnaataa iftiinka iftiinka iyo haze ee filimka baakadaha. Sida ka muuqata Jaantuska 3.4, ku darista Glycel iyo Sortol labaduba waxay saameeyeen astaamaha indhaha ee filimada HPMC, gaar ahaan haze. Jaantus 3.4 (a) waa garaaf muujinaya saamaynta ku saabsan injirka Glycel ee ku saabsan guryaha indhaha ee filimada HPMC. Iyada oo lagu daro Glycerol, goynta filimka filimada ee HPMC ayaa marka hore kordhay ka dibna uu hoos u dhacay, oo gaadhay qiimaha ugu sarreeya qiyaastii 0.25%; Haze wuxuu si dhakhso ah kor ugu samaaday ka dibna tartiib tartiib ayuu usii kordhay. Waxaa laga arki karaa falanqaynta kor ku xusan in marka lagu daro lacagta dheeriga ah ee glycel ay tahay 0.25%, sifooyinka indhaha ee filimka ayaa ka fiican, sidaa darteed lacagta isugeynta ee glycel waa inaysan ka badnaan 0.25%. Jaantus 3.4 (b) waa garaaf muujinaya saamaynta ku saabsan wax-ka-qabashada sirbol ee ku saabsan guryaha indhaha ee filimada HPMC. Waxaa lagu arki karaa tirada in lagu daro sartolka, xarkaha filimada HPMC ee ugu horeeya, ka dibna si tartiib tartiib ah ayuu u sii kordhayaa ka dibna kor u qaadida, iyo baararka ayaa marka hore kordhaya ka dibna kordha. Hoos u dhacday, iyo iftiinka transminge iyo hardeeca ayaa u muuqday kuwa ugu sarreeya isla waqtigaas marka tirada sixirku ay ahayd 0.45%. Waxaa la arki karaa in markii xaddiga sartotl lagu daray uu u dhexeeyo 0.35 iyo 0.45%, guryaha indhaha ayaa ka fiican. Isbarbardhigaya saameynta Glycel iyo Sortol on Guryaha indhaha ee filimada HPMC, waxaa lagu arki karaa in siribot ay saameyn yar ku leedahay astaamaha indhaha ee filimada.

Guud ahaan marka la hadlayo, alaabada waxgaradka iftiinka badan waxay lahaan doonaan hawo hoose, iyo dhanka kale, laakiin tani had iyo goor maahan kiiska. Qalabka qaar waxay leeyihiin wax qabad aad u sareeya, laakiin sidoo kale qiimayaasha haze, sida filimada khafiifka ah sida dhalada qabowga [73]. Filimka loo diyaariyey tijaabadan ayaa dooran kara balaastigga habboon ee ku habboon iyo lacagta lagu daro iyadoo loo eegayo baahida.

3.3.5 saameynta Glycerol iyo Sortol on Naafadda Biyaha ee Filimka HPMC

(a) glycerol (b) sirtol

Jaantus3.5 Saamaynta Glycerol ama Sorritlolon Biyaha Biyaha ee filimada HPMC

Jaantus 3.5 wuxuu muujinayaa saameynta Glycerol iyo Sortol oo ku saabsan xoolaha biyaha ee filimada HPMC. Waxaa lagu arki karaa tirada in kororka waxyaabaha ku jira balaastikada, waqtiga madax-xumada biyaha ee filimka HPMC si tartiib tartiib ah ayuu u yaraanayaa, iyo Glycerol waxay saameyn weyn ku leedahay xoolaha biyaha ee 'HPMC' oo ka mid ah SORMC. Sababta u ah in ay hydroxypropylpylylulose methylcelrellose ay leedahay culeys biyo ah oo wanaagsan sababta oo ah jiritaanka tiro badan oo ah kooxo badan oo hydroxyl ah oo ku yaal molecule. Laga soo bilaabo falanqaynta muuqaalka shaashadda ee xad-gudubka ah, waxaa lagu arki karaa in lagu daro glycerol iyo sobrol, oo muujinaya in tirada kooxaha hydroxyl ay hoos udhaceyso iyo kooxda biyaha hydrophiloplic-ka oo yaraada, sidaa darteed culeyska biyaha ee filimka HPMC ayaa hoos u dhacaya.

3.4 Qeybaha cutubkan

Iyada oo loo marayo falanqaynta waxqabadka ee kor ku xusan ee filimada HPMC, waxaa lagu arki karaa in glyceriorizisaropers glycerol iyo sirtol ay hagaajiyaan astaamaha farsamada ee filimada HPMC oo ay kordhiyaan dalagga kala jajabinta filimada. Marka lagu daro glycerol waa 0.15%, guryaha farsamada ee filimada HPMC waa wax aad u wanaagsan, xoogga khafiifka ah waa 60mpa, oo ku dhawaad ​​fasalku waa 50%; Marka lagu daro glycel waa 0.25%, guryaha indhaha ayaa ka fiican. Markii ay nuxurka Sorritolka yahay 0.15%, xoogga khafiifka ah ee filimka HPMC waa qiyaastii 55mpa, iyo wareegga nasashada ee ku kordha ilaa 45%. Marka ay ka kooban tahay sortol waa 0.45%, guryaha indhaha ee filimka ayaa ka fiican. Labada caagga ahba waxay yareeyeen xoolaha biyaha ee filimada HPMC, halka Sortlol saameyn yar ku yeeshay xoolaha biyaha ee filimada HPMC. Isbarbardhiga saameynta labada balaarri ee ku saabsan astaamaha filimada HPMC ayaa muujinaya in saameynta qalalaase ee Glycel ee Glycel ee filimada HPMC ay ka fiican tahay tan sixirdhiska.

Cutubka 4aad Saamaynta Wakiilada Isku-darka ee GUDDADA HIPMC Biyo-Xirmooyin

4.1 Hordhac

Hydroxypropylylkelrelolose waxaa ku jira kooxo badan oo hydroxyl iyo kooxo hydroxyproboxy, sidaa darteed waxay leedahay madax xanuun biyo ah. Waraaqdani waxay isticmaashaa jilicsanaanta biyaha ee wanaagsan si ay u diyaariso sheeko cagaaran oo biyuhu ku habboon yihiin iyo bey'adda u habboon ee kahadal. Iyada oo ku xidhan adeegsiga filimka biyaha-ku-militariga, kala diridda degdegga ah ee filimka biyaha-milka-ku-milma, laakiin mararka qaarkood dib u dhaca ayaa sidoo kale la doonayaa [21].

Sidaa darteed, cutubkan Glutaraldehyde waxaa loo isticmaalaa in wakiilka iskuxirka iskuxirka isku xidhka ee baakadaha biyaha ee xirmooyinka biyaha ee hydroxypropylyl methylrcellerose, oo dusha sare ay ka badato xaaska-lagu yareeyo biyaha iyo dib-u-dhigista waqtiga biyaha-suuxinta. Saameynta isku-darka mugga kala duwan ee glatraraldehy ee isku-dhafka biyaha, guryaha farsamada iyo guryaha indhaha ee vitalff of hydroxypropyl plutylcelrelose ayaa inta badan la bartay.

4.2 Qeybta Tijaabada

4.2.1 Qalabka tijaabada ah iyo aaladaha

Shaxda 4.1 Qalabka tijaabada ah iyo faahfaahinta

4.2.2 Diyaarinta Muujinta

1) Miisaankii: miisaan qaddar cayiman oo ah hydroxypropyl methylcelrelose (5%) oo leh dheelitirka elektiroonigga ah;

2) Kala diridda: miisaanka miisaanka hyroxypropyl metylcelrelolose waxaa lagu daraa biyaha loo diyaariyey ee loo diyaariyey, oo ay cadaadiska ah ka milmaan, oo ay si buuxda u taagnaato waqti cayiman, oo loo istcimaalo waqti cayiman dareere leh cagaaran oo glutaraldehy ah oo lagu daray ayaa la helaa;

3) Sameynta filimka

4.2.3 Cilmi-yaqaannada iyo Tijaabada Waxqabadka

4.2.3.1 NABADGELYADA FARSAMADA EE SPEROSCOPY (FT-IR)

Nugashifta aflagaado ah ee filimada HPMC waxaa lagu go'aamiyay iyadoo la adeegsanayo Nicolet 5700 ee Specereter offrometer ay soo saartay shirkadda Thermoletric-ka Mareykanka ee xiritaanka xiddigaha.

4.2.3.22 Raajo-xagal-xagal-xagal-wanaagga (XRD) Falanqaynta (XRD)

Kala-goynta xalka-xagal-xagal-xagal-xirashada (XRD) waa falanqaynta gobolka crystallization ee walaxda heerka molikalalar. Xaashidan, gobolka crystallization ee filimka khafiifka ah ayaa laga go'aamiyay iyadoo la adeegsanayo arl / x-xtra raajada kaladuwan ee ay soo saartay Thermor Arl ee Switzerland. Xaaladaha cabirka Shan xagal laga bilaabo 0 ° illaa 80 ° (2θ). Skaanka Skaanka 6 ° / min.

4.2.3.3 Go'aan ka gaarista salka dhexe ee biyaha: la mid ah 2.2.3.4

4.2.3.3 Go'aan ka gaarista guryaha farsamada

Isticmaalka aaladda (5943) Midab-goynta Tensile ee Turnaanta Turnaanta Turnaanta Turnaanta Turnaanta Turnile ee Turnile (Shanghai) Qalabka tijaabada ah ee GS13022-92 Xaaladaha Imtixaanka Geerida ee filimada caagga ah, 50% xaaladaha labiska ah, oo dusha sare ah oo aan ciladin lahayn.

4.2.3.3 Go'aaminta guryaha indhaha

Adeegsiga tijaabada khafiifka ah ee transmmer-ka iftiinka ah, xulo muunad lagu tijaabiyo dusha nadiifka ah oo aan cabir lahayn qadka, oo harqalka filimka heerkulka qolka (25 ° C iyo 50% rh).

4.2.4 Xogta xogta

Xogta tijaabada ah waxaa laga baaraandegay Excel oo lagu sawiray barnaamijyada asalka ah.

4.3 Natiijooyinka iyo wada hadalka

4.3.1 NABADGELYADA SAXIIXA EE GLATAREHE-GLATAREHYY-CROPLINKED FILMCS HPMC

Jawi

Infrated NABSECROSCOPOPY waa qaab awood badan oo lagu garto kooxaha waxqabadka ee kujira qaab dhismeedka molika iyo si loo garto kooxaha waxqabadka. Si loo fahmo isbeddelada qaab dhismeedka ee hydroxypropyl methylrcelrelosuse ka dib wax ka beddelka, tijaabooyin aflagaado ah ayaa lagu sameeyay filimada HPMC ka hor iyo ka dib wax ka beddelka. Jaantuska 4.1 wuxuu muujinayaa soo-celinta aflagaadada ee filimada HPMC ee leh qaddarro kaladuwan oo glutaraldehyde, iyo cilad-galka filimada HPMC

Dhaawaca dhaqdhaqaaqa dhaqdhaqaaqa ee loo yaqaan 'vakers' ee -hoh waxay ku dhowdahay 3418CM-1 iyo 1657CM-1. Isbarbardhigaya iskutallaabta iyo isgoysyada bilaa-galka ah ee aflagaadada ah ee HPMC, waxaa lagu arki karaa taas oo lagu daro in glutalehyde, peakros-ka-wareega 34crox-1 iyo 1657cm-ka-nuugista kooxda si weyn loo daciifiyey, taas oo muujineysa in tirada kooxaha hydroxyl) In molecule molecule ee HPMC la yareeyay, oo ay sababeen falcelinta isku xirka isku xirka ee ka dhexeysa kooxaha hydroxyl kooxo hydroxyl ee HPMC iyo kooxda Qandaraalka ee Glutaraldyde [74]. Intaas waxaa sii dheer, waxaa la ogaaday in lagu daro Glutaraldehyde ma uusan bedelin booska astaamaha sifeylis kasta oo kafaalaqaad ah ee HPMC, taasoo muujineysa in Glutaraldehyde uusan burburin kooxda HPMC lafteeda.

4.3.2 XRD Qaababka Glutarardehyde-Consplickled Filims HPMC

Adoo qabanaya raajo-kala-kala-baxa sheyga isla markaana falanqaynta qaabkeeda kaladuwan, waa hab cilmi baaris lagu helo macluumaadka sida qaabdhismeedka ama modolphology ee atomyada ama moleekulada gudaha maaddada. Jaantus 4.2 wuxuu muujinayaa qaababka XRD ee filimada HPMC oo leh isku-darka Glutaraldyden. Iyada oo la kordhiyey isugeynta Glutaraldehyde, xoogga xoogga badan ee kaladuwan ee HPMC qiyaastii 9.5 ° 20.5 ° 20.4 ° daciifka ah, maxaa yeelay aldehydes-ka ee ku jira geedka glutaraldehyde molecule. Fal-celinta iskutallaabta isku xirka waxay ka dhex dhacdaa kooxda hydroxyl group iyo kooxda hydroxyl ee molecule, kaas oo xadidaya dhaqdhaqaaqa silsiladda molikalalal ee '

Jaantus4.2 XRD ee filimada HPMC ee hoos timaada Nuttardehy-ka

4.3.3 Saamaynta Glutarardehyde ee ku saabsan xoolaha biyaha ee filimada HPMC

Jaantus4.3 Saamaynta Glutarardehyde ee ku saabsan xoolaha biyaha ee filimada HPMC

Jaantuska 4.3 Saamaynta Glutarardehyde Kala Duwan ee Naafadda Biyaha ee Filimada HPMC, waxaa lagu arki karaa in kororka qaddarka qaddarka qaawan, waqtiga madax-bannaanida biyaha ee filimada HPMC waa la dheereeyaa. Falanqaynta iskutallaabta isku xirka ayaa ka dhacda kooxda Aldehyde ee Glutarardehyde, taasoo dhalisay dhimis weyn oo ku saabsan tirada kooxaha hydroxyl ee molecule-ka biyaha ee HITMC, sidaas darteedna lagu yareeyo xariga biyaha ee filimka HPMC.

4.3.4 Saamaynta Glutarardehyde ee ku saabsan guryaha farsamada ee filimada HPMC

Sawirka

Si loo baaro saameynta ay ka kooban tahay walxaha keega ee dareeraha maskaxda ee filimada farsamada ee filimada 'HPMC', xoogga khafiifka ah iyo cidhifyada fasaxa filimada la beddelay ayaa la tijaabiyey. Tusaale ahaan, 4.4 waa garaafka saameynta ay ku jirto isku-darka Glutaraldehyde ee ku saabsan xoogga khasabka ah iyo ciribtirka jabinta filimka. Iyada oo la kordhiyo isugeynta Glutaraldehyde, xoogga khafiifka ah iyo ciribtirka fasaxa ee filimada HPMC ayaa kordhay marka hore ka dibna hoos u dhacay. isbeddelka. Maaddaama iskutallaabta iskuxirka ee Glutaraldyde iyo unugyada clutraldeose ay iskaa wax u qabso xirashada ka dib, ka dib markii ay ku dartay Glutaraldehyde Filimka Glucaldexyde iyo Hindroxyl-ka HPMC-ka ee ku saabsan qaabka iskuxiran ee HPMC-ka, kordhinta astaamaha farsamada ee HPMC filimada. Iyada oo lagu daro joornaalada Glutaraldehye, cufnaanta isku xirka xalka ee xalka, oo xadidaya qaraabada u dhexeysa dhaqdhaqaaqa xoogga, taas oo muujineysa in sifooyinka farsamada ee filimada khafiifka ah ee HPMC ay diidaan maqaac ahaan [76]]. Jaantuska 4.4, saamaynta Glutaraldyde ee guryaha farsamada ee filimada farsamada ee HPMC ayaa muujinaya in marka lagu daro Glutraldehyde waa mid ka fiican, oo sifooyinka farsamada ee filimada farsamada ayaa ka fiican.

4.3.5 Saamaynta Glutarardehyde ee ku saabsan guryaha indhaha ee filimada HPMC

Khafiifinta khafiifka ah iyo haragga ayaa ah laba cabirro wax qabad oo aad u muhiim ah oo filim ah oo ku saabsan filimada baakadaha. Tartanka weyn ee maleega, sida ugu fiican ee hufnaanta filimka; Haze, oo sidoo kale loo yaqaan xumaanta, wuxuu muujinayaa heerka aan caddayn filimka, iyo haze weyn, oo ka xun caddeynta filimka. Jaantusyada 4.5 waa qalooca qalooca ee ku darista Glutaraldehyde ee Glutarardenyde ee Guryaha indhaha ee filimada HPMC. Waxaa lagu arki karaa tirada kororka dheeriga ah ee glutaraldehyde, iftiinka transmindal-ka, wuxuu si tartiib tartiib ah u kordhaa, ka dibna si dhakhso ah ayuu u sii kordhiyaa ka dibna si tartiib ah ayuu u yaraanayaa; Haze wuxuu marka hore yaraaday ka dibna kordhay. Markii lagu daro Glutaraldehyde wuxuu ahaa 0.25%, in laga gudbayo filimka HPMC ee HPMC ay gaareen qiimaha ugu badan ee 93%, oo haze uu gaadhay qiimaha ugu yar ee 13%. Waqtigaan, waxqabadka indhaha ayaa ka fiicnaa. Sababta loo kordhiyo guryaha indhaha ayaa ah falcelinta isku xirka isku xirka ee ka dhexeysa molecules-ka glutaraldevelles iyo hydroxypropyl iyo labisku inuu yahay mid is haysta iyo labis badan, kaas oo kordhiya guryaha indhaha ee filimada HPMC [77-79]. Marka wakiilka iskutallaabta iskuxirka la isku xidho, bogagga iskutallaabta isku xirka ayaa lasiiyay, oo ah mid qaraabo ah oo u dhexeeya moleekulada nidaamka waa adag yahay, ifafaaleyaasha gel ayaa sahlan in la dhaco. Sidaa darteed, sifooyinka indhaha ee filimada HPMC waa la dhimay [80].

Jaantus4.5 Saamaynta Glutarardehyde ee hantida indhaha ee filimada HPMC

4.4 Qeybaha cutubkan

Falanqaynta kor ku xusan, gabagabadii soo socda ayaa la soo qaatay:

1) Spectrum offrum offrated ee filimka glutaraldehyde-ka-buuxinta

2) Waxay aad ugu habboon tahay in lagu daro glutaraldehyde inta u dhexeysa 0.25% illaa 0.44%. Marka lacagta lagu daro ee Glutaraldehyde waa 0.25%, guryaha farsamada gacanta iyo sifooyinka indhaha ee filimka HPMC ay ka fiican yihiin; Kadib isku xirka isku xirka, jilitaanka biyaha ee filimka HPMC Flive Find waa la dheereeyaa oo madax xanuunku waa la yareeyay. Marka lacagta lagu daro ee Glutaraldehyde waa 0.44%, waqtiga madax-xumada biyaha ay gaaraan qiyaastii 135min.

Cutubka 5aad ee dabiiciga ah ee dabiiciga ah ee loo yaqaan 'antioxidant hpmc'

5.1 Hordhac

Si loo ballaariyo arrinta ku saabsan adeegsiga hydroxypropyl platylcelrelose ee baakada cuntada, cutubkan wuxuu u adeegsadaa antioxidant-ka (antiox) oo ah antioxidant-ka dabiiciga ah si loo diyaariyo antioxida caleen dabiiciga ah oo lagu diyaariyo antioxidayaasha dabiiciga ah ee dabiiciga ah. Antioxidant HPMC Bog-ka-buuxinta filimka biyaha, barto guryaha antioxidant, jilitaanka biyaha, guryaha farsamada iyo astaamaha indhaha ee filimka, oo ay ku salaan codsigooda nidaamyada baakadaha cuntada.

5.2 Qeybta Tijaabada

5.2.1 Qalabka tijaabada ah iyo aaladaha tijaabada ah

Tab.5.1 Qalabka tijaabada ah iyo faahfaahinta

Tab.5.2 Qalabka tijaabada ah iyo faahfaahinta

5.2.2 Diyaarinta Muujinta

Diyaarso hydroxypropyl cluluylrcelrellose ee filimada biyaha ee leh caleenta caleenta caleenta ah ee loo yaqaan 'antioxyplopyl clutylrcelrcylyl', ka dibna ku dar @droxyplopyl methylcellcellcellcellcelllcelllcellcellus (0.04%, 0.03%, 0.03%, 0.03%, 0.03%, 0.03%, 0.03%, 0.03%, 0.07%, 0.09%) ee antioxidayaasha caleen ee caleen ee caleenta caleen caleenta caleen ee xalka unugyada unugyada unugyada, oo ay sii wadaan wada

Si aad si buuxda isugu qasmeyso, ha u istaagaan heerkulka qolka muddo ah 3-5 daqiiqo (dib-u-dhiska) si aad u diyaariso xalka filimka 'HPMC' ee ay ka kooban tahay jajabyo badan oo ka kooban antioxidayaasha caleenta ee bamboo caleenta. Ku qallaji foornada foosha xun, oo ku rid foornada qalajinta si aad u isticmaasho ka dib markii aad ka goysay filimka. Feejignaanta 'hyroxypropylpyl methylcelrellose metluyleglation-ka biyaha-ku-xadgudubka ee lagu daray bamboo caleenta caleenta caleenta ah waxaa loo tixraacayaa filimka AOB / HPMC ee gaaban.

5.2.3 Cilmi-yaqaannada iyo Tijaabada Waxqabadka

5.2.3.1 NABADGELYADA XARUNTA SPEROSCOPY (FT-IR)

Infrared ka maqnaanshaha filimada HPMC ayaa lagu cabiray qaabka Atr iyadoo la adeegsanayo Nicolet 5700 Gargaarka 5700 ee Beddelka Informatro mitir ee ay soo saartay Shirkadda Thermolectric.

5.2.3.22 Raajo-xagal-xagal-xagal-xagal

5.2.3.3 Go'aan ka gaarista guryaha antioxidant

Si loo cabiro astaamaha antioxidant ee filimada HPMC ee loo diyaariyey ee HPMC ee loo diyaariyey HPMC iyo Avmc Flivoles Fill-ka ah ee kacsan si loo cabbiro heerka muuqaalka ah ee finanka xagjirka ah, si aan si toos ah u cabir caabbinta oksidacation ee filimada.

Diyaarinta xalka 'DPPH' Ku keydi qaboojiyaha (4 ° C) isticmaalka dambe.

Iyaga oo tixraacaya habka tijaabada ah ee zhong yuankeng [81], oo leh wax ka badal yar, cabirka a0 ml oo biyo ah oo ka mid ah biyaha weelka ah si aad si buuxda u ruxdo oo aad u cabbireyso, oo cabir qiime (519nm) oo leh uv spectomotemeter-ka. waa a0. Cabbiraadda qiimaha Qaabka qiimeynta qiimeynta ee heerka xisaabinta heerka xisaabinta ee xalka ah ee loo yaqaan 'cppph' oo ah habka xisaabinta xisaabinta ee loo yaqaan 'chicing'

Qaaciddada: A waa xubinta muunadda; A0 waa xakamaynta maran

5.2.3.4 Go'aaminta guryaha farsamada: la mid ah 2.2.3.2

5.2.3.5 Go'aaminta guryaha indhaha

Guryaha indhaha ayaa ah tilmaamayaal muhiim ah oo ku saabsan daahfurnaanta filimada baakadaha, oo inta badan ay ku jiraan maleega iyo harooyinka filimka. Faafinta iyo harooyinka filimada ayaa lagu cabiray iyadoo la adeegsanayo tijaabada wadnaha. Iftiinka maleega iyo haze ee filimada waxaa lagu cabiray heerkulka qolka (25 ° C iyo 50% R r) oo ku saabsan sanballada imtixaanka oo leh sagxado nadiif ah oo aan lahayn fasal.

5.2.3.3 Go'aan ka gaarista Xaraashka Biyaha

Iska yaree 30mm × 30mm 30mm dhumuc weyn oo qiyaastii ah 45μm, ku dar 100ml oo biyo ah, ku rid filimka bartamaha dusha sare ee biyaha, oo cabir waqtiga filimka si uu u dhammaado gebi ahaanba. Haddii filimku ku dhejiyo derbiga garka, waxaa loo baahan yahay in mar labaad la cabiro, natiijadana waxaa loo qaadanayaa celcelis ahaan 3 jeer, cutubku waa min.

5.2.4 Xogta xog

Xogta tijaabada ah waxaa laga baaraandegay Excel oo lagu sawiray barnaamijyada asalka ah.

5.3 Natiijooyinka iyo Falanqaynta

5.3.1 falanqaynta FT-IR

Jaantuska

Moodhada dabiiciga ah, atomyada sameeya silsiladaha kiimikada ama kooxaha waxqabadka ayaa ku jira gabayg joogto ah. Marka moleekuleyaasha dabiiciga ah ee loo yaqaan 'organas-ka dabiiciga ah', dammaanad kiimikaad ama kooxo ku shaqeeya moleekulasku waxay nuugi karaan gariirkooda, sidaa darteed macluumaadka ku saabsan dammaanadda kiimikada ama kooxaha shaqeeya ee molecule-ka ayaa la heli karaa. Jaantus 5.1 wuxuu muujinayaa Ftiir Spectra Spectra ee Filimka HPMC ee HPMC iyo AB / HPMC. Jaantus 5, waxaa lagu arki karaa in galka qalfoofka qalfoofka ee hydroxypropyl methylcelrelolose ee methylcelrelolose ay inta badan urursan tahay 2600 ~ ~ 3700 cm-1 iyo 750 ~ 1700 cm-1. Soo noqnoqoshada adag ee gariirka ah ee 950-1250 gobol-1 ee gobolka CM-1 ayaa inta badan ah gobolka astaamaha loo yaqaan 'skeleton' oo gariiraya. Kooxda ka soo nuugista filimka HPMC ee ku dhow 3418 cm-1 waxaa sababa gariir fidsan ee debaajiga Oh, iyo heerka ugu sarreeya ee kooxda hyroxyl ee kooxda hyroxyproxyproxy ee 1657 cm-1 waxaa sababa gariirka fidinta Qaab-dhismeedka [82]. Kordhinta buufinta ee 1454cm-1, 1373cm-1, 1315cm-1 iyo 945cm-1 ayaa caadi ahaan loo gariiray asymmetric,-galka ciriiriga, ee diyaaradda, ee diyaaradda, ee diyaaradda iyo ka-tagida-ka-dhiska ah ee ay leeyihiin-83]. HPMC waxaa lagu habeeyay aOb. Iyada oo lagu daro AOB, booska ugu sarreeya ee astaamaha ee AOB / HPMC ma uusan beddelin, taasoo muujineysa in lagu daro in AOb aysan burburin kooxaha HPMC laftiisa. Gabababka fidinta ee 'Oh ee' Oh 'oo ku saabsan Filimka Kaabta / HPMC ee ku dhow 3418 cm-1 ayaa inta badan sababa isbedelka methylyl ee ku xigta iyo xargaha methylene-ka sababa dammaanadda hydrogen-ka. 12], waxaa la arki karaa in lagu daro inob uu saameyn ku yeesho boroska haynta hydrogen-ka ee dhexdhexaadka ah.

5.3.2 XRD Falanqaynta

Jaantus5.2 XRD ee HPMC iyo AOB /

Jaantus5.2 XRD ee HPMC iyo AUB / HPMC Flives

Xaaladda crystallone-ka ee filimada waxaa lagu falanqeeyey iyada oo raajo-xagal ballaaran-xagal ah. Jaantus 5.2 wuxuu muujinayaa qaababka XRD ee filimada HPMC iyo filimada AAOB / HPMC. Waxaa laga arki karaa tirada filimka HPMC uu leeyahay 2 meelood oo kaladuwan (9.5 °, 20.4 °). Iyada oo lagu daro AOB, oo ah wareegga kaladuwan qiyaastii 9.5 ° iyo 20.4 ° si weyn ayaa loo daciifiyey, taasoo muujineysa in moleekulka filimka ab / hpmc loo habeeyo hab nidaamsan. Awoodda hoos u dhacday, oo muujinaya in lagu daro in loo yaqaan 'ab uu carqaladeeyey qabanqaabada hydroxypropyl chlunylrcellerose ee moleculation, oo uu yareeyo qaab-dhismeedka asalka ah ee molecule, oo uu ka dhimay qaabka caadiga ah ee hydroxypropyl.

5.3.3 Guryaha antioxidant

Si loo sahamiyo saamaynta ku darista AOB ee kaladuwan ee caabbinta oksidation ee caabbinta ok / HPMC, filimada leh isku-darka kala duwan ee ab (0 ,.03%, 0.05%, 0.07%) ayaa la baaray, Saamaynta heerka qiiqa ee salka, natiijooyinka waxaa lagu muujiyey Jaantuska 5.3.

Jaantus5.3 Saamaynta filimada HPMC ee hoos timaada aob waxyaabaha ku jira ee ku saabsan DPP-ga Dengation

Waxaa lagu arki karaa Jaantuska 5.3 in lagu daro in antioxidant antioxidant uu si weyn u wanaajiyo heerka jahwareerka ee Filimaanta HPMC, taasina waa in lagu kordhiyo antiox ee filimada HPMC, iyo isbadalka antiox ee ay ka hortagaan aruurinta hore ayaa si tartiib tartiib ah u yaraaday. Marka lacagta lagu daro ee aOb waa 0.03%, filimka AOB / HPMC-ka ayaa saameyn ugu fiican ku leh heerka jahwareerka ee xagjiriinta bilaashka ah ee DPPH-da-dildication-ka ee 'DPPH', taasi waa, HPMC Filt-ka ee loo yaqaan 'oxidation' waqtigan; Marka ay ka kooban tahay ab ay ka kooban tahay 0.05% iyo 0.07%, heerka jajaban ee '' '' '' '' '' DPMC 'ayaa ka sarreysay kooxda 0.01%, laakiin si weyn uga hooseeya kooxda 0.03% kooxda ah. Tan waxaa laga yaabaa inay u sabab tahay antioxidayaasha dabiiciga ah ee xad-dhaafka ah ee loo yaqaan 'antioxidander' Waxaa la arki karaa in filimka AOB / HPMC ee loo diyaariyey tijaabada ay leedahay waxqabadka ka hortagga xudunta. Marka lacagta lagu daro waa 0.03%, waxqabadka ka hortagga xudunta ee filimka AOB / HPMC waa kan ugu xoogan.

5.3.4 Xoolaha biyaha

Jaantuska 5.4, saamaynta ay ku yeeshaan antioxidayaasha caleen ee caleen ee xaaska biyaha ee biyo-qabka hydroxypropylyldyl aflaanta filimyada '' ab ' Ka dib markii aad ku dartay AOB, oo kordhay tirada AOB, waqtiga biyaha ee filimka uu ka gaaban yahay, oo muujinaya in xaaska-xariga filimka AOB / HPMC uu ka fiicnaa. Taasi micnaheedu waa, ku darista AOB waxay wanaajisaa xariida biyaha ee AOB / HPMC ee filimka. Laga soo bilaabo falanqaynta XRD ee hore, waxaa la arki karaa ka dib markii lagu daro AOB, cryststallity of filimka AOB / HPMC ee u dhexeeya miraha-moleekulka si ay u galaan filimka ab / hpmc, sidaa darteed filimka AOB / HPMC waa la wanaajiyaa ilaa xad. Xaraashka biyaha ee filimka.

Sawirka

5.3.5 Hantida farsamada

Sawirka AOB

Adeegsiga ashyaa'da filimka khafiifka ah ayaa aad u ballaaran, iyo hantida farsamada ayaa saameyn weyn ku leh dhaqanka adeegga ee nidaamyada ku saleysan xuubka, taas oo noqotay hoteello sare ee cilmi baarista. Jaantus 5.5 wuxuu muujinayaa xoogga khafiifka ah iyo cirifka qalooca jabinta ee AUB / HPMC. Waxaa laga arki karaa tirada intaa ku-darrooyinka 'aOB kala duwan ay saameyn weyn ku yeeshaan guryaha farsamada ee filimada. Ka dib markii lagu daro AOB, iyadoo korodh kordhinta ab, AOB / HPMC. Awoodda togan ee filimka ayaa muujisay isbeddel xagga hoose ah, halka dalagga nasashada ay muujisay isbeddel marka hore sii kordhaya ka dib. Marka ay ka kooban tahay ab waxay ahayd 0.01%, qulqulka fasaxa filimka wuxuu gaadhay qiimaha ugu badnaan ee qiyaastii 45%. Saamaynta AOB ee guryaha farsamada ee filimada HPMC waa iska cadahay. Laga soo bilaabo falanqaynta XRD, waxaa la arki karaa in lagu daro in antioxidant Aob ay yareynayso cryststallinal-ka filimka AOB / HPMC, taasoo yareynaysa xoogga khasabka ah ee filimka AOB / HPMC. Qulqulka fasaxa marka hore kordhaya ka dibna yaraada, maxaa yeelay AOB wuxuu leeyahay culeys biyo ah oo wanaagsan iyo is-waafajin, waana walax yar oo molikal ah. Intii lagu gudajiray hannaanka is-waafajinta HPMC, waa in xoog is-dhexgal u dhexeeya molecules-ka la daciifiyo oo filimku wuu jilciyaa. Qaab-dhismeedka adag ayaa ka dhigaya filimka AOB / HPMC ee jilicsan iyo cidhifyada fasaxa filimka. Maaddaama AOB uu sii kordhayo, qulqulka nasashada filimka AOB / HPMC ee filimka ab / HPMC ma jiro wax fudud in la burburiyo marka filimka loo yaqaan 'lows' oo ah nasashada filimka ab / hpmc. hoos u dhaca.

5.3.6 Guryaha indhaha

Jaantus5.6 Saamaynta AOB ee hantida indhaha ee filimada HPMC

Jaantus 5.6 waa garaaf muujinaya isbedelka mareelinta iyo haze ee filimada AOB / HPMC. Waxaa lagu arki karaa tirada in la kordhiyo xaddiga AOB ee lagu daray, goynta filimka AOB / HPMC ee hoos udhacaya oo haze ayaa kordha. Markii ay ka koobnaaneynin AOb-ga kama uusan dhaafin Marka ay ku jirto ab-ga dhaaftay 0.05%, heerarka isbedelka ee khafiifka falabka iyo haradka ayaa dardar geliyay. Sidaa darteed, qadarka AOB in lagu daray waa inaysan ka badnayn 0.05%.

5.4 Qeybaha cutubkan

Qaadashada bamboo caleen caleen ah Filimka Baakadaha ee AOB / HPMC Filimka AOB / HPMC ee leh 0.03% Aob wuxuu leeyahay qiime jahwareer ah oo qiyaastii ah 89% ee xag-jirka ah ee DPPH, iyo hufnaanta isbadalka ayaa ah kuwa ugu fiican, taas oo ka fiican tan la'aan anoo la'aan. Filimka HPMC ee 61% ayaa la hagaajiyay. Xoolaha biyaha ayaa sidoo kale si weyn loo hagaajiyaa, oo guryaha farsamada iyo guryaha indhaha lagu yaraado. Iftiiminta hagaagaysa ee loo yaqaan 'oksidation'

CUTUBKA VI GUUD

1) Kordhinta fidinta xalka filimka 'HPMC' ee 'HPMC', oo ah astaamaha farsamada ee filimka ayaa markii ugu horreysay ee lagu soo kordhiyey ka dibna hoos u dhacay. Marka filimka loo yaqaan 'Filmiga Filimka DPMC' ee HPMC 'wuxuu ahaa 5%, sifooyinka farsamada ee filimka HPMC ayaa ka fiicnaa, xoogga khafiifka ah wuxuu ahaa 116mpa. Qulqulka fasaxa waa qiyaastii 31%; guryaha indhaha iyo hoos udhaca cunista biyaha.

2) Kordhinta heerkulka qaab-dhismeedka filimka, guryaha farsamada ee filimada ayaa marka hore kordhay ka dibna hoos u dhacay, guryaha indhaha ayaa la hagaajiyay, iyo saqafadda biyuhu hoos u dhacday. Marka heerkulka qaab-dhismeedka filimka uu yahay 50 ° C, waxqabadka guud waa ka fiican yahay, xoogga khafiifka ah waa qiyaastii 116mpa, transming transming-ka waa qiyaastii 95%, sidaa darteed heerkulka biyuhu waa 55 milyan oo heerkulka abuurka ah uu ku habboon yahay 50 ° C.

3) U adeegsiga qalabka caagga ah si loo wanaajiyo adkaanta filimada HPMC, oo lagu daro Glycerol, oo ah dib-u-dhigga filimka Finsile ee HPMC ayaa si weyn u kordhay, halka xoogga khafiifka ah uu hoos u dhacay. Marka qadarka Glycel uu ku daray wuxuu u dhexeeyey 0.15% iyo 0.25%, wareegga nasashada filimka HPMC wuxuu ahaa 50%, xoogga khafiifka ah wuxuu ahaa 60mpa.

4) Marka lagu daro sartolka, wareegga nasashada filimka ayaa marka hore kordhaya ka dibna wuu yaraanayaa. Marka lagu daro sartolka waa qiyaastii 0.15%, qulqulka nasashada oo gaar ah 45% oo xoogga khafiifka ah waa 55mpa.

5) Ku darista laba balaartijiyayaal, glycel iyo sartol, ayaa labaduba hoos u dhacay guryaha indhaha iyo xoolaha biyaha ee filimada 'HPMC', oo hoos udhaca ma ahayn wax weyn. Isbarbar dhigga saameynta lagula baco ee labada balaala oo ku saabsan filimada HPMC, waxaa lagu arki karaa in saamaynta qalalaase ee Glycel ay ka fiican tahay tan sixirbitol.

6) Iyada oo loo marayo maqnaanshaha infrated Spectroscopy (Ftiir) iyo xagal-raajada-raajada-raajada-raajada-xagal, isku-darka iskutallaabta glutarehyde iyo hpmc iyo crystallinal-ka iyo isku-darka ka dib isku xirnaanta isku xirka. Marka lagu daro wakiilka wakiilka isku xidhka ee Glutaraldehyde, xoogga khafiifka ah iyo wareegga fasaxa ee filimka HPMC ee loo diyaariyey ayaa marka hore kordhay ka dibna hoos u dhacay. Marka lagu daro Glutaraldehyde waa 0.25%, sifooyinka farsamada ee dhameystiran ee filimada HPMC ayaa ka fiican; Kadib markii iskuxirka isku xirka, waqtiga suuxdinta biyaha waa la dheereeyaa, iyo salka-xaliga. Marka lagu daro Glutaraldehyde waa 0.44%, waqtiga suuxdinta biyaha ayaa gaaraya qiyaastii 135min.

7) Ku darista qaddar ku habboon ee Antioxidant-ka AOB ee Filimka Filimka filimka HPMC / ee loo diyaariyey filimka 'ab' / HPMC ee baakadaha 'HPMC' ee ay leedahay astaamaha waxqabadka ee xididdada. Filimka AOB / HPMC ee leh 0.03% AOB ayaa lagu daray 0.03% AOB si ay u faafto ciriiriyada bilaashka ah Xoolaha biyaha ayaa sidoo kale si weyn loo hagaajiyaa, oo guryaha farsamada iyo guryaha indhaha lagu yaraado. Marka lagu daro ee ah 0.03% saameynta ka hortagga xulka filimka waa mid wanaagsan, iyo horumarka waxqabadka ka hortagga xulka AOB / HPMC ee Finjirta ee baakadaha xirmada.